Lindsay Hewlett
Overview
Explore the profile of Lindsay Hewlett including associated specialties, affiliations and a list of published articles.
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11
Citations
435
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Recent Articles
1.
Hewlett L, Zupancic G, Mashanov G, Knipe L, Ogden D, Hannah M, et al.
PLoS One
. 2011 Nov;
6(11):e27314.
PMID: 22096550
Background: Weibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca(2+)-driven WPB exocytosis is not known, although indirect evidence suggests that...
2.
Bailey J, OConnor V, Hannah M, Hewlett L, Biggs T, Sundstrom L, et al.
J Neurochem
. 2011 May;
117(6):1020-32.
PMID: 21592119
In this paper, we report the characterization of 'Hi-Spot' cultures formed by the re-aggregation of dissociated postnatal CNS tissue grown at an air-liquid interface. This produces a self-organised, dense, organotypic...
3.
Kiskin N, Hellen N, Babich V, Hewlett L, Knipe L, Hannah M, et al.
J Cell Sci
. 2010 Aug;
123(Pt 17):2964-75.
PMID: 20720153
Using fluorescence recovery after photobleaching (FRAP) we measured the mobilities of EGFP-tagged soluble secretory proteins in the endoplasmic reticulum (ER) and in individual Weibel-Palade bodies (WPBs) at early (immature) and...
4.
Knipe L, Meli A, Hewlett L, Bierings R, Dempster J, Skehel P, et al.
Blood
. 2010 Jun;
116(12):2183-91.
PMID: 20538801
Endothelial cells are reported to contain several distinct populations of regulated secretory organelles, including Weibel-Palade bodies (WPBs), the tissue plasminogen activator (tPA) organelle, and the type-2 chemokine-containing organelle. We show...
5.
Babich V, Knipe L, Hewlett L, Meli A, Dempster J, Hannah M, et al.
J Biol Chem
. 2009 Mar;
284(18):12459-68.
PMID: 19258324
Proteins secreted from Weibel-Palade bodies (WPBs) play important roles in regulating inflammatory and hemostatic responses. Inflammation is associated with the extracellular acidification of tissues and blood, conditions that can alter...
6.
Harrison-Lavoie K, Michaux G, Hewlett L, Kaur J, Hannah M, Lui-Roberts W, et al.
Traffic
. 2006 May;
7(6):647-62.
PMID: 16683915
The biogenesis of endothelial-specific Weibel-Palade bodies (WPB) is poorly understood, despite their key role in both haemostasis and inflammation. Biogenesis of specialized organelles of haemopoietic cells is often adaptor protein...
7.
Millan J, Hewlett L, Glyn M, Toomre D, Clark P, Ridley A
Nat Cell Biol
. 2006 Jan;
8(2):113-23.
PMID: 16429128
During inflammation, leukocytes bind to the adhesion receptors ICAM-1 and VCAM-1 on the endothelial surface before undergoing transendothelial migration, also called diapedesis. ICAM-1 is also involved in transendothelial migration, independently...
8.
Signoret N, Hewlett L, Wavre S, Pelchen-Matthews A, Oppermann M, Marsh M
Mol Biol Cell
. 2004 Dec;
16(2):902-17.
PMID: 15591129
The signaling activity of several chemokine receptors, including CC chemokine receptor 5 (CCR5), is in part controlled by their internalization, recycling, and/or degradation. For CCR5, agonists such as the chemokine...
9.
Burnett C, Makridou P, Hewlett L, Howard K
BMC Biochem
. 2004 Jan;
5:2.
PMID: 14725715
Background: Lipid phosphate phosphatases (LPPs) are integral membrane proteins believed to dephosphorylate bioactive lipid messengers, so modifying or attenuating their activities. Wunen, a Drosophila LPP homologue, has been shown to...
10.
Andrawiss M, Takeuchi Y, Hewlett L, Collins M
J Virol
. 2003 Oct;
77(21):11651-60.
PMID: 14557651
In order to track the assembly of murine leukemia virus (MLV), we used fluorescence microscopy to visualize particles containing Gag molecules fused to fluorescent proteins (FPs). Gag-FP chimeras budded from...