Linda H L Lua
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Explore the profile of Linda H L Lua including associated specialties, affiliations and a list of published articles.
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47
Citations
619
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Recent Articles
1.
Allard J, Aguirre M, Gupta R, Chua S, Shields K, Lua L
Chem Biol Interact
. 2024 Sep;
403:111219.
PMID: 39222902
Current medical countermeasures (MCMs) for nerve agent poisoning have limited efficacy, and can cause serious adverse effects, prompting the requirement for new broad-spectrum therapeutics. Human plasma-derived butyrylcholinseterase (huBChE) is a...
2.
Design and optimization of membrane chromatography for monoclonal antibody charge variant separation
Nadar S, Somasundaram B, Charry M, Billakanti J, Shave E, Baker K, et al.
Biotechnol Prog
. 2022 Jul;
38(6):e3288.
PMID: 35818846
The manufacturing scale implementation of membrane chromatography to purify monoclonal antibodies has gradually increased with the shift in industry focus toward flexible manufacturing and disposable technologies. Membrane chromatography are used...
3.
Allard J, Shields K, Munro T, Lua L
Chem Biol Interact
. 2022 Jun;
363:109996.
PMID: 35654125
Organophosphorus nerve agents represent a serious chemical threat due to their ease of production and scale of impact. The recent use of the nerve agent Novichok has re-emphasised the need...
4.
Tang S, Somasundaram B, Lua L
Methods Mol Biol
. 2022 Jan;
2406:93-111.
PMID: 35089552
Escherichia coli remains a traditional and widely used host organism for recombinant protein production. Its well-studied genome, availability of vectors and strains, cheap and relatively straight-forward cultivation methods paired with...
5.
Yap K, Du J, Rehm F, Tang S, Zhou Y, Xie J, et al.
Nat Protoc
. 2021 Feb;
16(3):1740-1760.
PMID: 33597770
Cyclic disulfide-rich peptides have attracted significant interest in drug development and biotechnology. Here, we describe a protocol for producing cyclic peptide precursors in Pichia pastoris that undergo in vitro enzymatic...
6.
Nadar S, Shooter G, Somasundaram B, Shave E, Baker K, Lua L
Biotechnol J
. 2020 Oct;
16(3):e2000309.
PMID: 33006254
The need to intensify downstream processing of monoclonal antibodies to complement the advances in upstream productivity has led to increased attention toward implementing membrane technologies. With the industry moving toward...
7.
Kamen A, Lua L, Mukhopadhyay T
Vaccine
. 2019 Oct;
37(47):6931-6932.
PMID: 31623914
No abstract available.
8.
Charlton Hume H, Vidigal J, Carrondo M, Middelberg A, Roldao A, Lua L
Biotechnol Bioeng
. 2019 Jan;
116(4):919-935.
PMID: 30597533
Vaccination is the most effective method of disease prevention and control. Many viruses and bacteria that once caused catastrophic pandemics (e.g., smallpox, poliomyelitis, measles, and diphtheria) are either eradicated or...
9.
Somasundaram B, Pleitt K, Shave E, Baker K, Lua L
Biotechnol Bioeng
. 2018 Aug;
115(12):2893-2907.
PMID: 30080940
Rapid advances in intensifying upstream processes for biologics production have left downstream processing as a bottleneck in the manufacturing scheme. Biomanufacturers are pursuing continuous downstream process development to increase efficiency...
10.
Walker J, Robinson K, Munro C, Gengenbach T, Muller D, Young P, et al.
Langmuir
. 2018 May;
35(5):1266-1272.
PMID: 29801414
Development of antifouling films which selectively capture or target proteins of interest is essential for controlling interactions at the "bio/nano" interface. However, in order to synthesize biofunctional films from synthetic...