Lina Greenberg
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Explore the profile of Lina Greenberg including associated specialties, affiliations and a list of published articles.
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20
Citations
273
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Recent Articles
1.
Garg A, Jansen S, Greenberg L, Zhang R, Lavine K, Greenberg M
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2405020121.
PMID: 39503885
Skeletal muscle actin (ACTA1) mutations are a prevalent cause of skeletal myopathies consistent with ACTA1's high expression in skeletal muscle. Rare de novo mutations in ACTA1 associated with combined cardiac...
2.
Walker E, Javati S, Todd E, Matlam J, Lin X, Bryant M, et al.
Nat Immunol
. 2024 Nov;
25(12):2247-2258.
PMID: 39496954
Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovation in prevention and treatment. Children in Papua New Guinea (PNG) experience profound morbidity from...
3.
Scott B, Greenberg L, Squarci C, Campbell K, Greenberg M
bioRxiv
. 2024 Oct;
PMID: 39416013
Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-year transplant-free survival rate is only ~50-70%. As such, there is a need to develop...
4.
Lin Z, Xie Y, Gongora J, Liu X, Zahn E, Palai B, et al.
bioRxiv
. 2024 Jun;
PMID: 38854050
Protein arginylation is an essential posttranslational modification (PTM) catalyzed by arginyl-tRNA-protein transferase 1 (ATE1) in mammalian systems. Arginylation features a post-translational conjugation of an arginyl to a protein, making it...
5.
Cubuk J, Greenberg L, Greenberg A, Emenecker R, Stuchell-Brereton M, Holehouse A, et al.
bioRxiv
. 2024 Jun;
PMID: 38853835
The cardiac troponin complex, composed of troponins I, T, and C, plays a central role in regulating the calcium-dependent interactions between myosin and the thin filament. Mutations in troponin can...
6.
Greenberg L, Stump W, Lin Z, Bredemeyer A, Blackwell T, Han X, et al.
bioRxiv
. 2024 Apr;
PMID: 38645235
Familial dilated cardiomyopathy (DCM) is frequently caused by autosomal dominant point mutations in genes involved in diverse cellular processes, including sarcomeric contraction. While patient studies have defined the genetic landscape...
7.
Ghahremani S, Kanwal A, Pettinato A, Ladha F, Legere N, Thakar K, et al.
Circulation
. 2024 Jan;
149(16):1285-1297.
PMID: 38235591
Background: truncation variants (TTNtvs) are the most common genetic lesion identified in individuals with dilated cardiomyopathy, a disease with high morbidity and mortality rates. TTNtvs reduce normal TTN (titin) protein...
8.
Lehman S, Meller A, Solieva S, Lotthammer J, Greenberg L, Langer S, et al.
bioRxiv
. 2023 Jul;
PMID: 37461648
In genetic cardiomyopathies, a frequently described phenomenon is how similar mutations in one protein can lead to discrete clinical phenotypes. One example is illustrated by two mutations in beta myosin...
9.
Barrick S, Garg A, Greenberg L, Zhang S, Lin C, Stitziel N, et al.
J Mol Cell Cardiol
. 2023 Feb;
176:58-67.
PMID: 36739943
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and a major indicator for heart transplant. Human genetic studies have identified over a thousand causal mutations for DCM in...
10.
Meller A, Lotthammer J, Smith L, Novak B, Lee L, Kuhn C, et al.
Elife
. 2023 Jan;
12.
PMID: 36705568
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently...