Lilach Simchi
Overview
Explore the profile of Lilach Simchi including associated specialties, affiliations and a list of published articles.
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6
Citations
59
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Recent Articles
1.
Sela M, Poley M, Mora-Raimundo P, Kagan S, Avital A, Kaduri M, et al.
Adv Mater
. 2023 Sep;
35(51):e2304654.
PMID: 37753928
Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although poor delivery to the brain hinders their therapeutic application. In the current study, it is demonstrated that brain-targeted liposomes...
2.
Simchi L, Gupta P, Feuermann Y, Kaphzan H
Mol Psychiatry
. 2023 Mar;
28(6):2382-2397.
PMID: 36991133
Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder caused by the maternally inherited loss of function of the UBE3A gene. AS is characterized by a developmental delay, lack of...
3.
Simchi L, Kaphzan H
Sci Rep
. 2021 Jan;
11(1):47.
PMID: 33420192
Angelman syndrome (AS) is a genetic neurodevelopmental disorder due to the absence of the E3-ligase protein, UBE3A. Inappropriate social interactions, usually hyper-sociability, is a part of that syndrome. In addition,...
4.
Panov J, Simchi L, Feuermann Y, Kaphzan H
Int J Mol Sci
. 2020 Jun;
21(11).
PMID: 32532103
The gene encodes the ubiquitin E3-ligase protein, UBE3A, which is implicated in severe neurodevelopmental disorders. Lack of UBE3A expression results in Angelman syndrome, while UBE3A overexpression, due to genomic 15q...
5.
Simchi L, Panov J, Morsy O, Feuermann Y, Kaphzan H
J Clin Med
. 2020 May;
9(5).
PMID: 32455880
The gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous...
6.
Koyavski L, Panov J, Simchi L, Rayi P, Sharvit L, Feuermann Y, et al.
Mol Neurobiol
. 2019 Feb;
56(9):5998-6016.
PMID: 30706369
Angelman syndrome (AS) is a genetic disorder which entails autism, intellectual disability, lack of speech, motor deficits, and seizure susceptibility. It is caused by the lack of UBE3A protein expression,...