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Liesl Nottingham

Explore the profile of Liesl Nottingham including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 215
Followers 0
Related Specialties
Oncology
Radiology
Top 10 Co-Authors
Carter Van Waes
Zhong Chen
Bin Yan
Clint T Allen
Jay Friedman
Praveen Duggal
Jianming Duan
Pattatheyil Arun
Gulshan Ara
Kathryn E King
Published In
Clin Cancer Res
Mol Cancer Ther
Cancer Res
Int J Radiat Oncol Biol Phys
Affiliations
Soon will be listed here.
Recent Articles
1.
TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer
Lu H, Yang X, Duggal P, Allen C, Yan B, Cohen J, et al.
Cancer Res . 2011 Sep; 71(21):6867-77. PMID: 21933882
Inflammation-induced activation of proto-oncogenic NF-κB/REL and dysfunction of tumor suppressor TP53/p63/p73 family transcription factors are key events in cancer progression. How inflammatory signaling coordinates dysregulation of these two transcription factor...
2.
Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer
Van Waes C, Allen C, Citrin D, Gius D, Colevas A, Harold N, et al.
Int J Radiat Oncol Biol Phys . 2009 Nov; 77(2):447-54. PMID: 19879702
Purpose: Epidermal growth factor receptor (EGFR) overexpression in head-and-neck squamous cell carcinoma (HNSCC) stimulates tumor cell proliferation, inhibits apoptosis, and increases chemotherapy and radiation resistance. We examined the toxicity, safety...
3.
Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms
Chen Z, Ricker J, Malhotra P, Nottingham L, Bagain L, Lee T, et al.
Mol Cancer Ther . 2008 Jul; 7(7):1949-60. PMID: 18645005
Head and neck squamous cell carcinomas (HNSCC) exhibit constitutive activation of transcription factors nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), which are modulated by the proteasome and promote resistance to...
4.
Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer
Allen C, Saigal K, Nottingham L, Arun P, Chen Z, Van Waes C
Clin Cancer Res . 2008 Jul; 14(13):4175-85. PMID: 18593997
Purpose: Nuclear factor-kappaB (NF-kappaB)/REL transcription factors promote cancer cell survival and progression. The canonical (NF-kappaB1/RELA or cREL) and alternate (NF-kappaB2/RELB) pathways require the proteasome for cytoplasmic-nuclear translocation, prompting the investigation...
5.
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer
Friedman J, Nottingham L, Duggal P, Pernas F, Yan B, Yang X, et al.
Clin Cancer Res . 2007 Nov; 13(22 Pt 1):6568-78. PMID: 18006756
Purpose: To determine the nature and potential pharmacologic reversibility of deficient TP53 expression and function in head and neck squamous cell carcinomas (HNSCC) with wild-type TP53, previously associated with decreased...
6.
Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma
Van Waes C, Yu M, Nottingham L, Karin M
Clin Cancer Res . 2007 Sep; 13(17):4956-9. PMID: 17785544
No abstract available.
7.
Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101
Duan J, Friedman J, Nottingham L, Chen Z, Ara G, Van Waes C
Mol Cancer Ther . 2007 Jan; 6(1):37-50. PMID: 17237265
Histone deacetylase inhibitors (HDI) can inhibit proliferation and enhance apoptosis in a wide range of malignancies. However, HDIs show relatively modest activity in head and neck squamous cell carcinomas (HNSCC),...