Ferhat Alkan
Overview
Explore the profile of Ferhat Alkan including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
350
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0
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Recent Articles
1.
Kyei-Baffour E, Lin Q, Alkan F, Faller W
Philos Trans R Soc Lond B Biol Sci
. 2025 Mar;
380(1921):20230381.
PMID: 40045778
Recent advances in the fields of RNA translation and ribosome biology have demonstrated the heterogeneous nature of ribosomes. This manifests not only across different cellular contexts but also within the...
2.
Birol N, Ciftci H, Yilmaz A, Caglayan A, Alkan F
Eur Arch Otorhinolaryngol
. 2025 Mar;
PMID: 40025183
Purpose: This study investigates the potential of the ChatGPT-4.0 artificial intelligence bot to assist speech-language pathologists (SLPs) by assessing its accuracy, comprehensiveness, and relevance in various tasks related to speech,...
3.
Ramalho S, Alkan F, Prekovic S, Jastrzebski K, Barbera E, Hoekman L, et al.
Sci Adv
. 2025 Jan;
11(2):eadn9750.
PMID: 39772672
Intestinal stem cells (ISCs) face the challenge of integrating metabolic demands with unique regenerative functions. Studies have shown an intricate interplay between metabolism and stem cell capacity; however, it is...
4.
Dopler A, Alkan F, Malka Y, van der Kammen R, Hoefakker K, Taranto D, et al.
Cell
. 2024 Oct;
187(24):6981-6993.e23.
PMID: 39437780
Inflammatory cytokines are pivotal to immune responses. Upon cytokine exposure, cells enter an "alert state" that enhances their visibility to the immune system. Here, we identified an alert-state subpopulation of...
5.
Lin C, Levy P, Alflen A, Apriamashvili G, Ligtenberg M, Vredevoogd D, et al.
Cancer Cell
. 2024 Mar;
42(4):623-645.e10.
PMID: 38490212
Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been systematically studied whether there are regulators that uniquely or broadly contribute to T cell fitness....
6.
Geissler A, Fehler A, Poulsen L, Gonzalez-Tortuero E, Kallehauge T, Alkan F, et al.
J Ind Microbiol Biotechnol
. 2022 Dec;
50(1).
PMID: 36564025
Yield improvements in cell factories can potentially be obtained by fine-tuning the regulatory mechanisms for gene candidates. In pursuit of such candidates, we performed RNA-sequencing of two α-amylase producing Bacillus...
7.
Malka Y, Alkan F, Ju S, Korner P, Pataskar A, Shulman E, et al.
Mol Cell
. 2022 Oct;
82(20):3840-3855.e8.
PMID: 36270248
The use of alternative promoters, splicing, and cleavage and polyadenylation (APA) generates mRNA isoforms that expand the diversity and complexity of the transcriptome. Here, we uncovered thousands of previously undescribed...
8.
Silva J, Alkan F, Ramalho S, Snieckute G, Prekovic S, Krotenberg Garcia A, et al.
Nat Commun
. 2022 Aug;
13(1):4492.
PMID: 35918345
The small intestine is a rapidly proliferating organ that is maintained by a small population of Lgr5-expressing intestinal stem cells (ISCs). However, several Lgr5-negative ISC populations have been identified, and...
9.
Alkan F, Wilkins O, Hernandez-Perez S, Ramalho S, Silva J, Ule J, et al.
Nucleic Acids Res
. 2022 Jun;
50(16):e95.
PMID: 35687114
Recent studies have revealed multiple mechanisms that can lead to heterogeneity in ribosomal composition. This heterogeneity can lead to preferential translation of specific panels of mRNAs, and is defined in...
10.
Corsi G, Qu K, Alkan F, Pan X, Luo Y, Gorodkin J
Nat Commun
. 2022 May;
13(1):3006.
PMID: 35637227
A major challenge of CRISPR/Cas9-mediated genome engineering is that not all guide RNAs (gRNAs) cleave the DNA efficiently. Although the heterogeneity of gRNA activity is well recognized, the current understanding...