Lianrong Wang
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Explore the profile of Lianrong Wang including associated specialties, affiliations and a list of published articles.
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64
Citations
2351
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Recent Articles
1.
An T, Tan Q, Jiang L, Liu L, Jiang X, Liu L, et al.
Nat Chem Biol
. 2025 Jan;
PMID: 39820821
In prokaryotes, the non-bridging oxygen in the DNA sugar-phosphate backbone can be enzymatically replaced by a sulfur atom, resulting in phosphorothioate (PT) modification. However, the mechanism underlying the oxygen-to-sulfur substitution...
2.
Tang Y, Wu D, Zhang Y, Liu X, Chu H, Tan Q, et al.
Nucleic Acids Res
. 2024 Nov;
52(22):13594-13604.
PMID: 39611571
Phosphorothioation serves as a DNA backbone modification mechanism, wherein a sulfur atom substitutes the nonbridging oxygen atom within the phosphodiester, facilitated by the gene products of dndABCDE or sspABCD. The...
3.
Wang L, Tang Y, Deng Z, Chen S
Annu Rev Microbiol
. 2024 Nov;
78(1):447-462.
PMID: 39565949
In contrast to the well-known DNA methylation of nucleobases, DNA phosphorothioate (PT) modification occurs in the DNA sugar-phosphate backbone. The non-bridging oxygen is replaced by a sulfur atom, which increases...
4.
Jiang S, Chen C, Huang W, He Y, Du X, Wang Y, et al.
Nat Microbiol
. 2024 Nov;
9(12):3226-3239.
PMID: 39506096
DNA degradation (Dnd) is a widespread bacterial antiphage defence system that relies on DNA phosphorothioate (PT) modification for self/non-self discrimination and subsequent degradation of unmodified DNA. Phages employ counterstrategies to...
5.
Zou X, Mo Z, Wang L, Chen S, Lee S
Small Methods
. 2024 Oct;
:e2400932.
PMID: 39359025
Bacteriophage contamination has a devastating impact on the viability of bacterial hosts and can significantly reduce the productivity of bioprocesses in biotechnological industries. The consequences range from widespread fermentation failure...
6.
Li Y, Wang L, Chen S
Med Res Rev
. 2024 Sep;
45(2):788-812.
PMID: 39318037
Mpox is a zoonotic illness caused by the Mpox virus (MPXV), a member of the Orthopoxvirus family. Although a few cases have been reported outside Africa, it was originally regarded...
7.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, et al.
Adv Sci (Weinh)
. 2024 Sep;
11(41):e2407709.
PMID: 39225620
Sortilin-related receptor 1 (SorL1) deficiency is a genetic predisposition to familial Alzheimer's disease (AD), but its pathology is poorly understood. In SorL1-null rats, a disorder of the global endosome-lysosome network...
8.
Chen L, Wu M, Chen S, Hu R, Wang Y, Zeng W, et al.
Adv Mater
. 2024 Aug;
36(38):e2407268.
PMID: 39091071
Clinical multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is the leading cause of refractory bacterial keratitis (BK). However, the reported BK treatment methods lack biosecurity and bioavailability, which usually causes irreversible visual impairment...
9.
Nie P, Zhang C, Wu F, Chen S, Wang L
Adv Sci (Weinh)
. 2024 Jun;
11(30):e2307751.
PMID: 38894550
Genomic instability is not only a hallmark of senescent cells but also a key factor driving cellular senescence, and replication stress is the main source of genomic instability. Defective prelamin...
10.
Wu Y, Zheng W, Xu G, Zhu L, Li Z, Chen J, et al.
Cell Death Differ
. 2024 May;
31(8):1070-1084.
PMID: 38816580
Sterol regulatory element binding transcription factors (SREBPs) play a crucial role in lipid homeostasis. They are processed and transported to the nucleus via COPII, where they induce the expression of...