Lian-Dong Guo
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Explore the profile of Lian-Dong Guo including associated specialties, affiliations and a list of published articles.
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12
Citations
49
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Recent Articles
1.
Guo L, Wu Y, Xu X, Lin Z, Tong R
Angew Chem Int Ed Engl
. 2023 Nov;
63(1):e202316259.
PMID: 37988261
Macrocycles with bent π-conjugation motif are extremely rare in nature and synthetically daunting and anticancer haouamines and spirohexenolides were representative of such rare natural products with synthetically challenging bent π-conjugation...
2.
Hu J, Guo L, Chen W, Jiang Y, Pu F, Ning C, et al.
Org Lett
. 2022 Oct;
24(40):7416-7420.
PMID: 36191161
Here, we report the first total syntheses of daphnezomine L-type alkaloids daphnezomine L methyl ester and calyciphylline K via late-stage C-N bond activation. The first synthesis of secodaphniphylline-type alkaloid caldaphnidine...
3.
Liang L, Guo L, Tong R
Acc Chem Res
. 2022 Aug;
55(16):2326-2340.
PMID: 35916456
The six-membered heterocycles containing oxygen and nitrogen (tetrahydropyrans, pyrans, piperidines) are among the most common heterocyclic structures ubiquitously present in bioactive molecules such as carbohydrates, small-molecule drugs, and natural products....
4.
Guo L, Xu Z, Tong R
Angew Chem Int Ed Engl
. 2021 Nov;
61(3):e202115384.
PMID: 34784090
Paspaline-derived indole diterpenes (IDTs) are structurally complex mycotoxins with unique tremorgenic activity. Reported are asymmetric total syntheses of three paspaline-derived IDTs paspalicine, paspalinine and paspalinine-13-ene. Our synthesis features a green...
5.
Guo L, Chen Y, Xu J
Acc Chem Res
. 2020 Oct;
53(11):2726-2737.
PMID: 33074659
Native to the Asia-Pacific region and widely applied in traditional Chinese medicine, the genus has produced over 330 known alkaloids. Investigations into these alkaloids have shown an exceptional range of...
6.
Guo L, Zhang Y, Hu J, Ning C, Fu H, Chen Y, et al.
Nat Commun
. 2020 Jul;
11(1):3538.
PMID: 32669587
Ever since Hirata's report of yuzurimine in 1966, nearly fifty yuzurimine-type alkaloids have been isolated, which formed the largest subfamily of the Daphniphyllum alkaloids. Despite extensive synthetic studies towards this...
7.
Guo L, Hu J, Zhang Y, Tu W, Zhang Y, Pu F, et al.
J Am Chem Soc
. 2019 Aug;
141(33):13043-13048.
PMID: 31381311
The synthetically challenging, diverse chemical skeletons and promising biological profiles of the alkaloids have generated intense interest from the synthetic chemistry community. Herein, the first and enantioselective total synthesis of...
8.
Guo L, Hou J, Tu W, Zhang Y, Zhang Y, Chen L, et al.
J Am Chem Soc
. 2019 Jul;
141(29):11713-11720.
PMID: 31299155
The intriguing structural complexity and bioactivities of the alkaloids have long attracted much attention. Herein, we report the first and enantioselective total synthesis of alkaloid dapholdhamine B and its lactone...
9.
Chen Y, Hu J, Guo L, Tian P, Xu T, Xu J
Org Lett
. 2019 May;
21(11):4309-4312.
PMID: 31141376
Daphniphyllum alkaloids daphnimacropodines A-C possess a highly congested ring system and share a common tetracyclic ring skeleton. To access the challenging chemical structure of daphnimacropodines, a divergent synthetic approach toward...
10.
Chen Y, Hu J, Guo L, Zhong W, Ning C, Xu J
Angew Chem Int Ed Engl
. 2019 Apr;
58(22):7390-7394.
PMID: 30958916
The daphniphyllum alkaloids are a structurally fascinating and remarkably diverse family of natural products. General strategies for the chemical synthesis of their challenging architectures are highly desirable for efficiently accessing...