Liam J McGuffin
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Explore the profile of Liam J McGuffin including associated specialties, affiliations and a list of published articles.
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64
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2383
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Recent Articles
1.
Taylor K, Elgheznawy A, Adiyaman R, Horn T, Parkes S, Hughes C, et al.
Haematologica
. 2025 Mar;
PMID: 40045892
Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels. Whilst Cx43 has garnered considerable...
2.
Genc A, McGuffin L
Methods Mol Biol
. 2024 Nov;
2867:121-139.
PMID: 39576578
Protein structure prediction is fundamental to molecular biology and has numerous applications in areas such as drug discovery and protein engineering. Machine learning techniques have greatly advanced protein 3D modeling...
3.
Maharaj A, Ishida M, Rybak A, Elfeky R, Andrews A, Joshi A, et al.
Nat Commun
. 2024 Sep;
15(1):8420.
PMID: 39341815
Postnatal growth failure is often attributed to dysregulated somatotropin action, however marked genetic and phenotypic heterogeneity exist. We report five patients from three families who present with short stature, immune...
4.
McGuffin L, Alharbi S
J Mol Biol
. 2024 Sep;
436(17):168531.
PMID: 39237204
Accurate models of protein tertiary structures are now available from numerous advanced prediction methods, although the accuracy of each method often varies depending on the specific protein target. Additionally, many...
5.
Edmunds N, Genc A, McGuffin L
Bioinformatics
. 2024 Aug;
40(8).
PMID: 39115813
Motivation: Despite an increase in protein modelling accuracy following the development of AlphaFold2, there remains an accuracy gap between predicted and observed model quality assessment (MQA) scores. In CASP15, variations...
6.
Gerencer M, McGuffin L
Front Immunol
. 2023 Jul;
14:1177691.
PMID: 37492575
The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that the RGD motif binding integrin(s) may play an important...
7.
Adiyaman R, Edmunds N, Genc A, Alharbi S, McGuffin L
Bioinform Adv
. 2023 Jun;
3(1):vbad078.
PMID: 37359722
Motivation: The accuracy gap between predicted and experimental structures has been significantly reduced following the development of AlphaFold2 (AF2). However, for many targets, AF2 models still have room for improvement....
8.
Edmunds N, Alharbi S, Genc A, Adiyaman R, McGuffin L
Proteins
. 2023 Jun;
91(12):1871-1878.
PMID: 37314190
In CASP15, there was a greater emphasis on multimeric modeling than in previous experiments, with assembly structures nearly doubling in number (41 up from 22) since the previous round. CASP15...
9.
McGuffin L, Edmunds N, Genc A, Alharbi S, Salehe B, Adiyaman R
Nucleic Acids Res
. 2023 Apr;
51(W1):W274-W280.
PMID: 37102670
The IntFOLD server based at the University of Reading has been a leading method over the past decade in providing free access to accurate prediction of protein structures and functions....
10.
Adiyaman R, McGuffin L
Methods Mol Biol
. 2023 Mar;
2627:119-140.
PMID: 36959445
The refinement of predicted 3D models aims to bring them closer to the native structure by fixing errors including unusual bonds and torsion angles and irregular hydrogen bonding patterns. Refinement...