Liam J Holt
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Explore the profile of Liam J Holt including associated specialties, affiliations and a list of published articles.
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1645
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Recent Articles
1.
Valverde-Mendez D, Sunol A, Bratton B, Delarue M, Hofmann J, Sheehan J, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(4):e2406340121.
PMID: 39854229
The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich...
2.
Ding X, Hao H, Elnatan D, Alinaya P, Kalra S, Kaur A, et al.
bioRxiv
. 2025 Jan;
PMID: 39829784
Understanding how cells control their biophysical properties during development remains a fundamental challenge. While cytoplasmic macromolecular crowding affects multiple cellular processes in single cells, its regulation in living animals remains...
3.
Mays J, Mei S, Kogenaru M, Quysbertf H, Bosco N, Zhao X, et al.
bioRxiv
. 2024 Oct;
PMID: 39386620
Investigating chromosomal instability and aneuploidy within tumors is essential for understanding tumorigenesis and developing diagnostic and therapeutic strategies. Single-cell DNA sequencing technologies have enabled such analyses, revealing aneuploidies specific to...
4.
Xie Y, Shu T, Liu T, Spindler M, Mahamid J, Hocky G, et al.
Mol Cell
. 2024 Jul;
84(14):2698-2716.e9.
PMID: 39059370
The cell interior is packed with macromolecules of mesoscale size, and this crowded milieu significantly influences cellular physiology. Cellular stress responses almost universally lead to inhibition of translation, resulting in...
5.
Hernandez C, Duran-Chaparro D, van Eeuwen T, Rout M, Holt L
bioRxiv
. 2024 Jul;
PMID: 39005449
The mechanisms that regulate the physical properties of the cell interior remain poorly understood, especially at the mesoscale (10nm-100nm). Changes in these properties have been suggested to be crucial for...
6.
Valverde-Mendez D, Sunol A, Bratton B, Delarue M, Hofmann J, Sheehan J, et al.
bioRxiv
. 2024 Apr;
PMID: 38585850
The crowded bacterial cytoplasm is comprised of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich...
7.
Holt L, Delarue M
Curr Opin Cell Biol
. 2023 Oct;
85:102269.
PMID: 37897928
All living cells are crowded with macromolecules. Crowding can directly modulate biochemical reactions to various degrees depending on the sizes, shapes, and binding affinities of the reactants. Here, we explore...
8.
Shu T, Mitra G, Alberts J, Viana M, Levy E, Hocky G, et al.
bioRxiv
. 2023 Oct;
PMID: 37781612
The mesoscale organization of molecules into membraneless biomolecular condensates is emerging as a key mechanism of rapid spatiotemporal control in cells. Principles of biomolecular condensation have been revealed through reconstitution....
9.
Xie Y, Liu T, Gresham D, Holt L
bioRxiv
. 2023 Jul;
PMID: 37398029
The intracellular environment is packed with macromolecules of mesoscale size, and this crowded milieu significantly influences cell physiology. When exposed to stress, mRNAs released after translational arrest condense with RNA...
10.
Devany J, Falk M, Holt L, Murugan A, Gardel M
Dev Cell
. 2023 Jun;
58(16):1462-1476.e8.
PMID: 37339629
Cell proliferation is a central process in tissue development, homeostasis, and disease, yet how proliferation is regulated in the tissue context remains poorly understood. Here, we introduce a quantitative framework...