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Leyao Shen

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Articles 17
Citations 250
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Recent Articles
1.
Luo Z, He Y, Wu H, Li Y, Shen L, Cheng L, et al.
Int Endod J . 2024 Sep; 57(12):1700-1716. PMID: 39287434
Background: Postoperative endodontic pain (PEP) is crucial in clinical practice. Recently, the effects of various laser adjuvant therapies in endodontic treatments have been widely evaluated. However, as a virtually side-effect-free...
2.
Yang D, Wang Y, Qi T, Zhang X, Shen L, Ma J, et al.
Neuron . 2024 Jan; 112(6):959-971.e8. PMID: 38266644
For decades, the expression of immediate early genes (IEGs) such as FOS has been the most widely used molecular marker representing neuronal activation. However, to date, there is no equivalent...
3.
Li X, Shen L, Deng Z, Huang Z
Precis Clin Med . 2023 Jun; 6(2):pbad014. PMID: 37333626
Osteoarthritis is a complex degenerative disease that affects the entire joint tissue. Currently, non-surgical treatments for osteoarthritis focus on relieving pain. While end-stage osteoarthritis can be treated with arthroplasty, the...
4.
Yang D, Wang Y, Qi T, Zhang X, Shen L, Ma J, et al.
bioRxiv . 2023 Mar; PMID: 36993270
For decades, the expression of immediate early genes (IEGs) such as c- has been the most widely used molecular marker representing neuronal activation. However, to date, there is no equivalent...
5.
Shen L, Yu Y, Karner C
Front Physiol . 2022 Oct; 13:992679. PMID: 36213239
Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation,...
6.
Shen L, Karner C
J Vis Exp . 2022 May; (182). PMID: 35499335
Bone development and homeostasis is dependent upon the differentiation and activity of bone forming osteoblasts. Osteoblast differentiation is sequentially characterized by proliferation followed by protein synthesis and ultimately bone matrix...
7.
Shen L, Yu Y, Zhou Y, Pruett-Miller S, Zhang G, Karner C
Elife . 2022 Mar; 11. PMID: 35261338
Cellular differentiation is associated with the acquisition of a unique protein signature that is essential to attain the ultimate cellular function and activity of the differentiated cell. This is predicted...
8.
Zhang H, Puviindran V, Nadesan P, Ding X, Shen L, Tang Y, et al.
J Bone Miner Res . 2022 Feb; 37(5):983-996. PMID: 35220602
Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant, respectively. The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been...
9.
Shen L, Hu G, Karner C
Curr Osteoporos Rep . 2022 Feb; 20(1):53-64. PMID: 35112289
Purpose Of Review: Osteoblasts are responsible for bone matrix production during bone development and homeostasis. Much is known about the transcriptional regulation and signaling pathways governing osteoblast differentiation. However, less...
10.
Lin Z, Yu K, Shen L, Zhang Y, Liu Y, Hou M, et al.
Reprod Fertil Dev . 2021 Oct; 33(14):782-797. PMID: 34663492
As the only viviparous reptile in China that has both temperature-dependent sex determination (TSD) and genetic-dependent sex determination (GSD) mechanisms, Eremias multiocellata is considered as an ideal species for studying...