Lev P Ovchinnikov
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Explore the profile of Lev P Ovchinnikov including associated specialties, affiliations and a list of published articles.
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34
Citations
1272
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Recent Articles
1.
Sogorina E, Kim E, Sorokin A, Lyabin D, Ovchinnikov L, Mordovkina D, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008856
YB-1 is a multifunctional DNA- and RNA-binding protein involved in cell proliferation, differentiation, and migration. YB-1 is a predominantly cytoplasmic protein that is transported to the nucleus in certain conditions,...
2.
Budkina K, El Hage K, Clement M, Desforges B, Bouhss A, Joshi V, et al.
Nucleic Acids Res
. 2021 Sep;
49(17):10061-10081.
PMID: 34469566
In the absence of the scanning ribosomes that unwind mRNA coding sequences and 5'UTRs, mRNAs are likely to form secondary structures and intermolecular bridges. Intermolecular base pairing of non polysomal...
3.
Samsonova A, El Hage K, Desforges B, Joshi V, Clement M, Lambert G, et al.
Commun Biol
. 2021 Mar;
4(1):359.
PMID: 33742080
The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression. Although Lin28 blocks let-7 microRNA maturation, Lin28 also binds to a large set...
4.
Mordovkina D, Lyabin D, Smolin E, Sogorina E, Ovchinnikov L, Eliseeva I
Biomolecules
. 2020 Apr;
10(4).
PMID: 32290447
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse,...
5.
Kretov D, Mordovkina D, Eliseeva I, Lyabin D, Polyakov D, Joshi V, et al.
Cells
. 2020 Jan;
9(1).
PMID: 31906126
The Y-box binding protein 1 (YB-1) is an RNA/DNA-binding protein regulating gene expression in the cytoplasm and the nucleus. Although mostly cytoplasmic, YB-1 accumulates in the nucleus under stress conditions....
6.
Eliseeva I, Vasilieva M, Ovchinnikov L
Genes (Basel)
. 2019 Feb;
10(2).
PMID: 30700035
The mammalian target of rapamycin (mTOR) kinase is a well-known master regulator of growth-dependent gene expression in higher eukaryotes. Translation regulation is an important function of the mTORC1 pathway that...
7.
Kretov D, Clement M, Lambert G, Durand D, Lyabin D, Bollot G, et al.
Nucleic Acids Res
. 2019 Jan;
47(6):3127-3141.
PMID: 30605522
The structural rearrangements accompanying mRNA during translation in mammalian cells remain poorly understood. Here, we discovered that YB-1 (YBX1), a major partner of mRNAs in the cytoplasm, forms a linear...
8.
Mordovkina D, Kim E, Buldakov I, Sorokin A, Eliseeva I, Lyabin D, et al.
Biochem Biophys Res Commun
. 2016 Nov;
480(4):629-634.
PMID: 27794479
The DNA/RNA-binding protein YB-1 (Y-box binding protein 1) performs multiple functions both in the cytoplasm and the nucleus of the cell. Generally localized to the cytoplasm, under certain conditions YB-1...
9.
Alemasova E, Pestryakov P, Sukhanova M, Kretov D, Moor N, Curmi P, et al.
Biochimie
. 2015 Oct;
119:36-44.
PMID: 26453809
Multifunctional Y-box binding protein 1 (YB-1) is actively studied as one of the components of cellular response to genotoxic stress. However, the precise role of YB-1 in the process of...
10.
Kretov D, Curmi P, Hamon L, Abrakhi S, Desforges B, Ovchinnikov L, et al.
Nucleic Acids Res
. 2015 Aug;
43(19):9457-73.
PMID: 26271991
Translation is tightly regulated in cells for keeping adequate protein levels, this task being notably accomplished by dedicated mRNA-binding proteins recognizing a specific set of mRNAs to repress or facilitate...