Leticia Perez-Sisques
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Explore the profile of Leticia Perez-Sisques including associated specialties, affiliations and a list of published articles.
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11
Citations
64
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Recent Articles
1.
Campoy-Campos G, Solana-Balaguer J, Guisado-Corcoll A, Chicote-Gonzalez A, Garcia-Segura P, Perez-Sisques L, et al.
Nucleic Acids Res
. 2024 Sep;
52(18):11158-11176.
PMID: 39268577
RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer's disease (AD) that contributes to cognitive deficits and neuroinflammation. Here, we found that RTP801 interacts with HSPC117, DDX1...
2.
Perez-Sisques L, Bhatt S, Matuleviciute R, Gileadi T, Kramar E, Graham A, et al.
J Neurosci
. 2024 Apr;
44(19).
PMID: 38575342
The histone lysine demethylase KDM5B is implicated in recessive intellectual disability disorders, and heterozygous, protein-truncating variants in are associated with reduced cognitive function in the population. The KDM5 family of...
3.
Solana-Balaguer J, Martin-Flores N, Garcia-Segura P, Campoy-Campos G, Perez-Sisques L, Chicote-Gonzalez A, et al.
J Extracell Vesicles
. 2023 Nov;
12(11):e12378.
PMID: 37932242
Extracellular vesicles (EVs) play a crucial role in intercellular communication, participating in the paracrine trophic support or in the propagation of toxic molecules, including proteins. RTP801 is a stress-regulated protein,...
4.
Solana-Balaguer J, Campoy-Campos G, Martin-Flores N, Perez-Sisques L, Sitja-Roqueta L, Kucukerden M, et al.
J Extracell Vesicles
. 2023 Sep;
12(9):e12355.
PMID: 37743539
Extracellular vesicles (EVs) play an important role in intercellular communication as carriers of signalling molecules such as bioactive miRNAs, proteins and lipids. EVs are key players in the functioning of...
5.
Cordoba-Jover B, Ribera J, Portoles I, Lecue E, Rodriguez-Vita J, Perez-Sisques L, et al.
Liver Int
. 2023 Jun;
43(8):1822-1836.
PMID: 37312667
Background & Aims: Transcription co-activator factor 20 (TCF20) is a regulator of transcription factors involved in extracellular matrix remodelling. In addition, TCF20 genomic variants in humans have been associated with...
6.
Garrido A, Perez-Sisques L, Simonet C, Campoy-Campos G, Solana-Balaguer J, Martin-Flores N, et al.
Ann Neurol
. 2022 Aug;
92(5):888-894.
PMID: 35929078
The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in...
7.
Perez-Sisques L, Solana-Balaguer J, Campoy-Campos G, Martin-Flores N, Sancho-Balsells A, Vives-Isern M, et al.
Biomolecules
. 2022 Jan;
12(1).
PMID: 35053183
RTP801/REDD1 is a stress-regulated protein whose levels are increased in several neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases (HD). RTP801 downregulation ameliorates behavioral abnormalities in several mouse models...
8.
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease
Perez-Sisques L, Sancho-Balsells A, Solana-Balaguer J, Campoy-Campos G, Vives-Isern M, Soler-Palazon F, et al.
Cell Death Dis
. 2021 Jun;
12(6):616.
PMID: 34131105
RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death. Its downregulation in Parkinson's and Huntington's disease models ameliorates the pathological phenotypes. In the context...
9.
Perez-Sisques L, Martin-Flores N, Masana M, Solana-Balaguer J, Llobet A, Romani-Aumedes J, et al.
Exp Neurol
. 2021 May;
342:113755.
PMID: 33984337
Background: RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death in in vitro and in vivo models of Parkinson's and Huntington's diseases and is...
10.
Martin-Flores N, Perez-Sisques L, Creus-Muncunill J, Masana M, Gines S, Alberch J, et al.
Cell Death Dis
. 2020 Aug;
11(7):569.
PMID: 32732871
RTP801/REDD1 is a stress-responsive protein that mediates mutant huntingtin (mhtt) toxicity in cellular models and is up regulated in Huntington's disease (HD) patients' putamen. Here, we investigated whether RTP801 is...