Lesley T Cutcliffe
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Explore the profile of Lesley T Cutcliffe including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Shima K, Wanker M, Skilton R, Cutcliffe L, Schnee C, Kohl T, et al.
mSphere
. 2018 Oct;
3(5).
PMID: 30305318
We demonstrate the genetic transformation of using a plasmid shuttle vector system which generates stable transformants. The equine N16 isolate harbors the 7.5-kb plasmid pCpnE1. We constructed the plasmid vector...
2.
Andersson P, Harris S, Smith H, Hadfield J, ONeill C, Cutcliffe L, et al.
Nat Commun
. 2016 Feb;
7:10688.
PMID: 26912299
Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from...
3.
Wang Y, Cutcliffe L, Skilton R, Ramsey K, Thomson N, Clarke I
Pathog Dis
. 2014 Apr;
72(1):19-23.
PMID: 24700815
The development of genetic transformation technology for Chlamydia trachomatis using its endogenous plasmid has recently been described. Chlamydia muridarum cannot be transformed by the C. trachomatis plasmid, indicating a barrier...
4.
Sigar I, Schripsema J, Wang Y, Clarke I, Cutcliffe L, Seth-Smith H, et al.
Pathog Dis
. 2013 Sep;
70(1):61-9.
PMID: 24022847
We hypothesized that the plasmid of urogenital isolates of Chlamydia trachomatis would modulate infectivity and virulence in a mouse model. To test this hypothesis, we infected female mice in the...
5.
Wang Y, Cutcliffe L, Skilton R, Persson K, Bjartling C, Clarke I
Pathog Dis
. 2013 Apr;
67(2):100-3.
PMID: 23620154
The development of a plasmid-based genetic transformation protocol for Chlamydia trachomatis provides the basis for the detailed investigation of the function of the chlamydial plasmid and its individual genes or...
6.
Wang Y, Kahane S, Cutcliffe L, Skilton R, Lambden P, Persson K, et al.
PLoS One
. 2013 Mar;
8(3):e59195.
PMID: 23527131
Our study had three objectives: to extend the plasmid-based transformation protocol to a clinical isolate of C. trachomatis belonging to the trachoma biovar, to provide "proof of principle" that it...
7.
Seth-Smith H, Harris S, Skilton R, Radebe F, Golparian D, Shipitsyna E, et al.
Genome Res
. 2013 Mar;
23(5):855-66.
PMID: 23525359
The use of whole-genome sequencing as a tool for the study of infectious bacteria is of growing clinical interest. Chlamydia trachomatis is responsible for sexually transmitted infections and the blinding...
8.
Labiran C, Clarke I, Cutcliffe L, Wang Y, Skilton R, Persson K, et al.
Front Cell Infect Microbiol
. 2012 Aug;
2:68.
PMID: 22919659
We aimed to evaluate the stability of the Chlamydia trachomatis multi locus VNTR analysis (MLVA-ompA) and multi sequence typing (MST) systems through multiple passages in tissue culture. Firstly, we analyzed...
9.
Harris S, Clarke I, Seth-Smith H, Solomon A, Cutcliffe L, Marsh P, et al.
Nat Genet
. 2012 Mar;
44(4):413-9, S1.
PMID: 22406642
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited....
10.
Wang Y, Kahane S, Cutcliffe L, Skilton R, Lambden P, Clarke I
PLoS Pathog
. 2011 Oct;
7(9):e1002258.
PMID: 21966270
Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary...