Les Coulton
Overview
Explore the profile of Les Coulton including associated specialties, affiliations and a list of published articles.
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15
Citations
434
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Recent Articles
1.
Gascoyne D, Spearman H, Lyne L, Puliyadi R, Perez-Alcantara M, Coulton L, et al.
PLoS One
. 2015 Jun;
10(6):e0128513.
PMID: 26034982
Mutations of the forkhead transcription factor FOXP2 gene have been implicated in inherited speech-and-language disorders, and specific Foxp2 expression patterns in neuronal populations and neuronal phenotypes arising from Foxp2 disruption...
2.
Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone
Galli G, de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, et al.
PLoS Genet
. 2012 May;
8(5):e1002711.
PMID: 22589746
PRDM family members are transcriptional regulators involved in tissue specific differentiation. PRDM5 has been reported to predominantly repress transcription, but a characterization of its molecular functions in a relevant biological...
3.
Mohanty S, Kottam L, Gambardella A, Nicklin M, Coulton L, Hughes D, et al.
Arthritis Res Ther
. 2010 Jul;
12(4):R149.
PMID: 20649960
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may...
4.
Chantry A, Heath D, Mulivor A, Pearsall S, Baudhuin M, Coulton L, et al.
J Bone Miner Res
. 2010 Jun;
25(12):2633-46.
PMID: 20533325
Cancers that grow in bone, such as myeloma and breast cancer metastases, cause devastating osteolytic bone destruction. These cancers hijack bone remodeling by stimulating osteoclastic bone resorption and suppressing bone...
5.
Cai G, Yang L, Saleh M, Coulton L
J Pediatr Orthop B
. 2010 Apr;
19(5):441-5.
PMID: 20389258
Is the articular cartilage of the immature ankle joint damaged by tibial lengthening? Sixteen immature rabbits underwent a 30% diaphyseal lengthening by tibial callotasis. Damage was assessed by scanning electronic...
6.
Deleu S, Lemaire M, Arts J, Menu E, Van Valckenborgh E, Vande Broek I, et al.
Cancer Res
. 2009 Jun;
69(13):5307-11.
PMID: 19531653
The proteasome inhibitor bortezomib (Velcade) is currently approved as second-line treatment of multiple myeloma (MM). MM-related bone disease is one of the most debilitating complications of MM. Besides supportive care...
7.
Heath D, Chantry A, Buckle C, Coulton L, Shaughnessy Jr J, Evans H, et al.
J Bone Miner Res
. 2008 Nov;
24(3):425-36.
PMID: 19016584
Multiple myeloma (MM) is associated with the development of osteolytic bone disease, mediated by increased osteoclastic bone resorption and impaired osteoblastic bone formation. Dickkopf-1 (Dkk1), a soluble inhibitor of wingless/int...
8.
Lawson M, Coulton L, Ebetino F, Vanderkerken K, Croucher P
Biochem Biophys Res Commun
. 2008 Oct;
377(2):453-457.
PMID: 18929536
Geranylgeranyl transferase II (GGTase II) is an enzyme that plays a key role in the isoprenylation of proteins. 3-PEHPC, a novel GGTase II inhibitor, blocks bone resorption and induces myeloma...
9.
Cai G, Yang L, Saleh M, Coulton L
J Pediatr Orthop B
. 2007 Oct;
16(6):403-7.
PMID: 17909337
Limb lengthening by tibial callotasis is usually performed in the metaphysis but may cause growth inhibition. Is diaphyseal lengthening more advantageous? Sixteen immature rabbits underwent 30% diaphyseal lengthening by tibial...
10.
Menu E, Jernberg-Wiklund H, De Raeve H, De Leenheer E, Coulton L, Gallagher O, et al.
Int J Cancer
. 2007 Jun;
121(8):1857-61.
PMID: 17546599
During the last decade, a central role for insulin-like growth factor 1 (IGF-1) in the pathophysiology of multiple myeloma (MM) has been well established. IGF-I provided by the tumor-microenvironment interaction...