Leonidas Tsiokas
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Explore the profile of Leonidas Tsiokas including associated specialties, affiliations and a list of published articles.
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38
Citations
1400
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Recent Articles
11.
Gamage T, Lengle E, Gunnes G, Pullisaar H, Holmgren A, Reseland J, et al.
Cell Calcium
. 2019 Dec;
85:102110.
PMID: 31785581
Calcium signaling plays a central role in bone development and homeostasis. Store operated calcium entry (SOCE) is an important calcium influx pathway mediated by calcium release activated calcium (CRAC) channels...
12.
Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, et al.
Cell Rep
. 2018 Feb;
22(6):1560-1573.
PMID: 29425510
Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We...
13.
Feng S, Streets A, Nesin V, Tran U, Nie H, Onopiuk M, et al.
J Am Soc Nephrol
. 2017 Jun;
28(10):2973-2984.
PMID: 28620080
Autosomal dominant polycystic kidney disease (ADPKD) is caused by inactivating mutations in (85%) or (15%). The ADPKD proteins encoded by these genes, polycystin-1 (PC1) and polycystin-2 (PC2), form a plasma...
14.
Chakraborty P, Mustafi S, Xiong X, Dwivedi S, Nesin V, Saha S, et al.
Nat Commun
. 2017 May;
8:14634.
PMID: 28530221
Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca uptake, Mitochondrial Calcium Uptake 1...
15.
Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai C, et al.
Nat Cell Biol
. 2016 May;
18(7):752-764.
PMID: 27214281
WNT ligands induce Ca(2+) signalling on target cells. PKD1 (polycystin 1) is considered an orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2), a Ca(2+)-permeable ion channel. Inactivating...
16.
Keeling J, Tsiokas L, Maskey D
Cells
. 2016 Feb;
5(1).
PMID: 26840332
Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development,...
17.
Maskey D, Marlin M, Kim S, Kim S, Ong E, Li G, et al.
EMBO J
. 2015 Jul;
34(19):2424-40.
PMID: 26206584
Primary cilia start forming within the G1 phase of the cell cycle and continue to grow as cells exit the cell cycle (G0). They start resorbing when cells re-enter the...
18.
Nesin V, Tsiokas L
Handb Exp Pharmacol
. 2014 Apr;
222:15-51.
PMID: 24756701
The TRPC1 ion channel was the first mammalian TRP channel to be cloned. In humans, it is encoded by the TRPC1 gene located in chromosome 3. The protein is predicted...
19.
Nesin V, Wiley G, Kousi M, Ong E, Lehmann T, Nicholl D, et al.
Proc Natl Acad Sci U S A
. 2014 Mar;
111(11):4197-202.
PMID: 24591628
Signaling through the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel regulates critical cellular functions, including gene expression, cell growth and differentiation, and Ca(2+) homeostasis. Loss-of-function mutations in the CRAC channel pore-forming...
20.
Ong E, Nesin V, Long C, Bai C, Guz J, Ivanov I, et al.
J Biol Chem
. 2013 Jun;
288(31):22219-32.
PMID: 23770672
Ca(2+) signaling is essential for bone homeostasis and skeletal development. Here, we show that the transient receptor potential canonical 1 (TRPC1) channel and the inhibitor of MyoD family, I-mfa, function...