Leonid B Heifets
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Explore the profile of Leonid B Heifets including associated specialties, affiliations and a list of published articles.
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8
Citations
319
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Recent Articles
1.
van Ingen J, Totten S, Helstrom N, Heifets L, Boeree M, Daley C
Antimicrob Agents Chemother
. 2012 Oct;
56(12):6324-7.
PMID: 23027189
Disease caused by nontuberculous mycobacteria (NTM) is increasing in frequency. The outcome of treatment for NTM lung disease is poor, particularly lung disease caused by Mycobacterium simiae and M. abscessus....
2.
The pharmacokinetics and pharmacodynamics of pulmonary Mycobacterium avium complex disease treatment
van Ingen J, Egelund E, Levin A, Totten S, Boeree M, Mouton J, et al.
Am J Respir Crit Care Med
. 2012 Jun;
186(6):559-65.
PMID: 22744719
Rationale: Currently recommended multidrug treatment regimens for Mycobacterium avium complex (MAC) lung disease yield limited cure rates. This results, in part, from incomplete understanding of the pharmacokinetics and pharmacodynamics of...
3.
van Ingen J, Totten S, Heifets L, Boeree M, Daley C
Int J Antimicrob Agents
. 2011 Nov;
39(2):173-6.
PMID: 22099521
The Mycobacterium simiae complex bacteria can cause opportunistic infections in humans. In the case of definite disease, there are no evidence-based treatment regimens and outcomes are very disappointing. To increase...
4.
van Ingen J, Boeree M, van Soolingen D, Iseman M, Heifets L, Daley C
Infect Genet Evol
. 2011 Nov;
12(4):832-7.
PMID: 22036704
Phylogenetic analyses on the basis of multiple house-keeping genes and whole genome sequences have offered new insights in the phylogeny of the genus Mycobacterium. This genus yields obligate pathogens, the...
5.
van Ingen J, de Lange W, Boeree M, Iseman M, Daley C, Heifets L, et al.
Lancet Infect Dis
. 2011 Jul;
11(8):585.
PMID: 21798459
No abstract available.
6.
Chung W, Kornilov A, Brodsky B, Higgins M, Sanchez T, Heifets L, et al.
Tuberculosis (Edinb)
. 2008 Aug;
88(5):410-9.
PMID: 18674969
Pyrazinamide is unusual among anti-tuberculous agents in its ability to promote a durable cure and shorten the duration of therapy. Yet the basis for this effect is not well understood....
7.
8.
Fennelly K, Martyny J, Fulton K, Orme I, Cave D, Heifets L
Am J Respir Crit Care Med
. 2003 Dec;
169(5):604-9.
PMID: 14656754
The concentration and size distribution of infectious aerosols produced by patients with pulmonary tuberculosis (TB) has never been directly measured. We aimed to assess the feasibility of a method that...