Leonard Shultz
Overview
Explore the profile of Leonard Shultz including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
558
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Recent Articles
1.
Abeynaike S, Huynh T, Mehmood A, Kim T, Frank K, Gao K, et al.
Viruses
. 2023 Feb;
15(2).
PMID: 36851579
Mice reconstituted with human immune systems are instrumental in the investigation of HIV-1 pathogenesis and therapeutics. Natural killer (NK) cells have long been recognized as a key mediator of innate...
2.
Stripecke R, Munz C, Schuringa J, Bissig K, Soper B, Meeham T, et al.
EMBO Mol Med
. 2020 Jun;
12(7):e8662.
PMID: 32578942
Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can...
3.
Serr I, Furst R, Achenbach P, Scherm M, Gokmen F, Haupt F, et al.
Nat Commun
. 2016 Mar;
7:10991.
PMID: 26975663
Immune tolerance is executed partly by Foxp3(+)regulatory T (Treg) cells, which suppress autoreactive T cells. In autoimmune type 1 diabetes (T1D) impaired tolerance promotes destruction of insulin-producing β-cells. The development...
4.
Jurczyk A, Nowosielska A, Przewozniak N, Aryee K, DiIorio P, Blodgett D, et al.
FASEB J
. 2015 Nov;
30(2):983-93.
PMID: 26546129
Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes (T2D) than the general population (18-30 vs. 1.2-6.3%), independent of body mass index and antipsychotic medication,...
5.
Guendel I, Iordanskiy S, Van Duyne R, Kehn-Hall K, Saifuddin M, Das R, et al.
J Virol
. 2013 Nov;
88(2):1189-208.
PMID: 24227837
The implementation of new antiretroviral therapies targeting transcription of early viral proteins in postintegrated HIV-1 can aid in overcoming current therapy limitations. Using high-throughput screening assays, we have previously described...
6.
Zhang B, Li M, McDonald T, Holyoake T, Moon R, Campana D, et al.
Blood
. 2013 Jan;
121(10):1824-38.
PMID: 23299311
Tyrosine kinase inhibitors (TKIs) are highly effective in treatment of chronic myeloid leukemia (CML) but do not eliminate leukemia stem cells (LSCs), which remain a potential source of relapse. TKI...
7.
Bernstein J, Lehman H, Lis M, Sands A, Wilding G, Shultz L, et al.
Ann Otol Rhinol Laryngol
. 2012 Jun;
121(5):307-16.
PMID: 22724276
Objectives: To determine whether MUC gene expression could be down-regulated in nasal polyps by the leukotriene receptor antagonist montelukast, we developed a system in which nondisrupted human nasal polyps could...
8.
Duyne R, Narayanan A, K-Hall K, Saifuddin M, Shultz L, Kashanchi F
Curr HIV Res
. 2012 Jan;
9(8):595-605.
PMID: 22211664
The existence of long-lasting cellular reservoirs of HIV-1 is one of the major hurdles in developing effective anti-retroviral therapies. These latently infected cells and tissues efficiently evade immune responses and...
9.
Zhang B, Strauss A, Chu S, Li M, Ho Y, Shiang K, et al.
Cancer Cell
. 2010 May;
17(5):427-42.
PMID: 20478526
Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients but does not eliminate leukemia stem cells (LSCs), which remain a potential source of relapse. Here we investigated the...
10.
Yamamoto T, Kaizu C, Kawasaki T, Hasegawa G, Umezu H, Ohashi R, et al.
Cell Tissue Res
. 2008 Mar;
332(2):245-56.
PMID: 18335245
We previously reported that macrophage colony-stimulating factor (M-CSF, CSF-1) played important roles in the process of the repopulation of Kupffer cells after their elimination by administration of liposome-entrapped dichloromethylene diphosphonate...