Leonard H Damelin
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Explore the profile of Leonard H Damelin including associated specialties, affiliations and a list of published articles.
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11
Citations
108
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Recent Articles
1.
Harris L, van Zyl L, Kirby-McCullough B, Damelin L, Tiemessen C, Trindade M
Plasmid
. 2018 Sep;
98:56-62.
PMID: 30240699
The vaginal mucosa is dominated by Gram positive, rod shaped lactobacilli which serve as a natural barrier against infection. In both healthy- and bacterial vaginosis (BV)-infected women Lactobacillus crispatus and...
2.
Mynhardt C, Damelin L, Jivan R, Peres J, Prince S, Veale R, et al.
J Cell Biochem
. 2017 Jul;
119(1):1193-1203.
PMID: 28722177
5-Fluorouracil (5-FU) is a chemotherapeutic agent used to treat a variety of gastric cancers including oesophageal squamous cell carcinoma (OSCC), for which the 5-year mortality rate exceeds 85%. Our study...
3.
Damelin L, Fernandes M, Tiemessen C
Int J Antimicrob Agents
. 2015 Jul;
46(4):394-400.
PMID: 26184337
In sub-Saharan Africa, human immunodeficiency virus (HIV) infections are predominantly acquired via heterosexual contact, and women are at greatest risk of being infected. This region also has the highest rates...
4.
Damelin L, Paximadis M, Mavri-Damelin D, Birkhead M, Lewis D, Tiemessen C
J Med Microbiol
. 2010 Oct;
60(Pt 2):180-183.
PMID: 21030503
Lactobacillus jensenii, Lactobacillus crispatus, Lactobacillus iners, Lactobacillus gasseri and Lactobacillus vaginalis were identified by 16S rRNA gene sequencing as the predominant culturable vaginal Lactobacillus species in a group of South...
5.
Damelin L, Mavri-Damelin D, Klaenhammer T, Tiemessen C
Appl Environ Microbiol
. 2010 Apr;
76(12):3878-85.
PMID: 20418431
Vaginal mucosal microfloras are typically dominated by Gram-positive Lactobacillus species, and colonization of vaginal mucosa by exogenous microbicide-secreting Lactobacillus strains has been proposed as a means of enhancing this natural...
6.
Mavri-Damelin D, Wilden J, Mani A, Selden C, Hodgson H, Damelin L
Bioconjug Chem
. 2009 Jan;
20(2):266-73.
PMID: 19140729
We present a labeling system for direct chemiluminescence-based cellular bioassays using the stable pro-chemiluminescent, luminol precursor, 3-aminophthalimide (API). API-coupled reporter molecules are detected chemiluminometrically after treatment with hydrazine, which converts...
7.
Mavri-Damelin D, Damelin L, Eaton S, Rees M, Selden C, Hodgson H
Biotechnol Bioeng
. 2007 Aug;
99(3):644-51.
PMID: 17680661
Extrahepatic bioartificial liver devices should provide an intact urea cycle to detoxify ammonia. The C3A cell line, a subclone of the hepatoma-derived HepG2 cell line, is currently used in this...
8.
Damelin L, Coward S, Kirwan M, Collins P, Selden C, Hodgson H
J Cell Biochem
. 2007 Jan;
101(3):723-34.
PMID: 17211854
The mechanisms by which steatosis renders hepatocytes susceptible to damage in non-alcoholic steatohepatitis (NASH) are unclear although fat accumulation is believed to increase hepatocyte susceptibility to inflammatory cytokines and oxidative...
9.
Mavri-Damelin D, Eaton S, Damelin L, Rees M, Hodgson H, Selden C
Int J Biochem Cell Biol
. 2006 Nov;
39(3):555-64.
PMID: 17098461
A possible cell source for a bio-artificial liver is the human hepatblastoma-derived cell line HepG2 as it confers many hepatocyte functions, however, the urea cycle is not maintained resulting in...
10.
Damelin L, Coward S, Choudhury S, Chalmers S, Cox I, Robertson N, et al.
Arch Biochem Biophys
. 2004 Nov;
432(2):167-77.
PMID: 15542055
Cultures of hepatocytes and HepG2 cells provide useful in vitro models of liver specific function. In this study, we investigated metabolic and biosynthetic function in 3-D HepG2 spheroid cultures, in...