Leonard C Schalkwyk
Overview
Explore the profile of Leonard C Schalkwyk including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
89
Citations
6097
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Wong C, Smith R, Hannon E, Ramaswami G, Parikshak N, Assary E, et al.
Hum Mol Genet
. 2019 Jun;
28(13):2201-2211.
PMID: 31220268
Autism spectrum disorder (ASD) encompasses a collection of complex neuropsychiatric disorders characterized by deficits in social functioning, communication and repetitive behaviour. Building on recent studies supporting a role for developmentally...
12.
Gorrie-Stone T, Smart M, Saffari A, Malki K, Hannon E, Burrage J, et al.
Bioinformatics
. 2019 Mar;
35(6):981-986.
PMID: 30875430
Motivation: The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and datasets containing thousands of samples, analyses of these large datasets using...
13.
OBrien H, Hannon E, Hill M, Toste C, Robertson M, Morgan J, et al.
Genome Biol
. 2018 Nov;
19(1):194.
PMID: 30419947
Background: Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have...
14.
Hannon E, Gorrie-Stone T, Smart M, Burrage J, Hughes A, Bao Y, et al.
Am J Hum Genet
. 2018 Nov;
103(5):654-665.
PMID: 30401456
Characterizing the complex relationship between genetic, epigenetic, and transcriptomic variation has the potential to increase understanding about the mechanisms underpinning health and disease phenotypes. We undertook a comprehensive analysis of...
15.
Marzi S, Leung S, Ribarska T, Hannon E, Smith A, Pishva E, et al.
Nat Neurosci
. 2018 Oct;
21(11):1618-1627.
PMID: 30349106
We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel sequencing. We observed...
16.
Spiers H, Hannon E, Schalkwyk L, Bray N, Mill J
BMC Genomics
. 2017 Sep;
18(1):738.
PMID: 28923016
Background: Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring...
17.
Janecka M, Haworth C, Ronald A, Krapohl E, Happe F, Mill J, et al.
J Am Acad Child Adolesc Psychiatry
. 2017 Apr;
56(5):383-390.
PMID: 28433087
Objective: Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal...
18.
Janecka M, Marzi S, Parsons M, Liu L, Paya-Cano J, Smith R, et al.
Sci Rep
. 2017 Feb;
7:41204.
PMID: 28145470
Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous...
19.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, et al.
Hum Mol Genet
. 2016 Dec;
26(1):210-225.
PMID: 28011714
Genetic association studies provide evidence for a substantial polygenic component to schizophrenia, although the neurobiological mechanisms underlying the disorder remain largely undefined. Building on recent studies supporting a role for...
20.
Malki K, Tosto M, Mourino-Talin H, Rodriguez-Lorenzo S, Pain O, Jumhaboy I, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2016 Oct;
174(3):235-250.
PMID: 27696737
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized, with many genetic variants interacting in yet unclear ways. In this study we used methods that...