Leonard Bell
Overview
Explore the profile of Leonard Bell including associated specialties, affiliations and a list of published articles.
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7
Citations
1120
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Recent Articles
1.
Upton R, Bell L, Guy C, Caldwell P, Estdale S, Barran P, et al.
Anal Chem
. 2016 Sep;
88(20):10259-10265.
PMID: 27620140
In the development of therapeutic antibodies and biosimilars, an appropriate biopharmaceutical CMC control strategy that connects critical quality attributes with mechanism of action should enable product assessment at an early...
2.
Firth D, Bell L, Squires M, Estdale S, McKee C
Anal Biochem
. 2015 Jun;
485:34-42.
PMID: 26070852
We present the demonstration of a rapid "middle-up" liquid chromatography mass spectrometry (LC-MS)-based workflow for use in the characterization of thiol-conjugated maleimidocaproyl-monomethyl auristatin F (mcMMAF) and valine-citrulline-monomethyl auristatin E (vcMMAE)...
3.
Hill A, Rother R, Wang X, Morris Jr S, Quinn-Senger K, Kelly R, et al.
Br J Haematol
. 2010 Mar;
149(3):414-25.
PMID: 20230403
Pulmonary hypertension (PH) is a common complication of haemolytic anaemia. Intravascular haemolysis leads to nitric oxide (NO) depletion, endothelial and smooth muscle dysregulation, and vasculopathy, characterized by progressive hypertension. PH...
4.
Rother R, Rollins S, Mojcik C, Brodsky R, Bell L
Nat Biotechnol
. 2007 Nov;
25(11):1256-64.
PMID: 17989688
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation can lead to severe pathology. In the rare hemolytic disease paroxysmal nocturnal hemoglobinuria (PNH), somatic mutations result...
5.
Hillmen P, Muus P, Duhrsen U, Risitano A, Schubert J, Luzzatto L, et al.
Blood
. 2007 Aug;
110(12):4123-8.
PMID: 17702897
Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic disorders. In paroxysmal nocturnal hemoglobinuria (PNH) patients, hemolysis can contribute to thromboembolism (TE), the most feared complication in PNH, and...
6.
Rother R, Bell L, Hillmen P, Gladwin M
JAMA
. 2005 Apr;
293(13):1653-62.
PMID: 15811985
Context: The efficient sequestration of hemoglobin by the red blood cell membrane and the presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent the buildup of this...
7.
Mathew J, Shernan S, White W, Fitch J, Chen J, Bell L, et al.
Stroke
. 2004 Aug;
35(10):2335-9.
PMID: 15331798
Background And Purpose: Pharmacological modulation of complement activation recently has been postulated as a therapeutic target in the treatment of neurological injury. We hypothesized that pexelizumab, a humanized scFv monoclonal...