Leon van Gurp
Overview
Explore the profile of Leon van Gurp including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1167
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Recent Articles
1.
Perez-Frances M, Bru-Tari E, Cohrs C, Abate M, van Gurp L, Furuyama K, et al.
Nat Metab
. 2024 Aug;
6(9):1791-1806.
PMID: 39169271
Insulin-producing β-cells in pancreatic islets are regulated by systemic cues and, locally, by adjacent islet hormone-producing 'non-β-cells' (namely α-cells, δ-cells and γ-cells). Yet whether the non-β-cells are required for accurate...
2.
van Gurp L, Fodoulian L, Oropeza D, Furuyama K, Bru-Tari E, Vu A, et al.
Nat Commun
. 2024 Mar;
15(1):2574.
PMID: 38519459
No abstract available.
3.
Zomer A, Croci D, Kowal J, van Gurp L, Joyce J
iScience
. 2022 Jun;
25(7):104570.
PMID: 35769877
Tumors evolve in a dynamic communication with their native tissue environment and recruited immune cells. The diverse components of the tumor microenvironment (TME) can critically regulate tumor progression and therapeutic...
4.
van Gurp L, Fodoulian L, Oropeza D, Furuyama K, Bru-Tari E, Vu A, et al.
Nat Commun
. 2022 Apr;
13(1):2020.
PMID: 35440614
Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular...
5.
Perez-Frances M, van Gurp L, Abate M, Cigliola V, Furuyama K, Bru-Tari E, et al.
Nat Commun
. 2021 Sep;
12(1):5783.
PMID: 34580307
No abstract available.
6.
Perez-Frances M, van Gurp L, Abate M, Cigliola V, Furuyama K, Bru-Tari E, et al.
Nat Commun
. 2021 Jul;
12(1):4458.
PMID: 34294685
The cellular identity of pancreatic polypeptide (Ppy)-expressing γ-cells, one of the rarest pancreatic islet cell-type, remains elusive. Within islets, glucagon and somatostatin, released respectively from α- and δ-cells, modulate the...
7.
van Gurp L, Muraro M, Dielen T, Seneby L, Dharmadhikari G, Gradwohl G, et al.
Development
. 2019 Jun;
146(12).
PMID: 31160419
During pancreatic development, endocrine cells appear from the pancreatic epithelium when Neurog3-positive cells delaminate and differentiate into α-, β-, γ- and δ-cells. The mechanisms involved in this process are still...
8.
Furuyama K, Chera S, van Gurp L, Oropeza D, Ghila L, Damond N, et al.
Nature
. 2019 Feb;
567(7746):43-48.
PMID: 30760930
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In...
9.
Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, et al.
Nat Cell Biol
. 2018 Oct;
20(11):1267-1277.
PMID: 30361701
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1-2% of the glucagon-producing α-cells spontaneously engage in insulin production...
10.
Loomans C, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, et al.
Stem Cell Reports
. 2018 Mar;
10(3):712-724.
PMID: 29539434
Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion...