Leon G Tertoolen
Overview
Explore the profile of Leon G Tertoolen including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
438
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Recent Articles
1.
Vicente-Steijn R, Kelder T, Tertoolen L, Wisse L, Pijnappels D, Poelmann R, et al.
Cardiovasc Res
. 2017 Sep;
113(10):1186-1197.
PMID: 28899000
Aims: RHOA-ROCK signalling regulates cell migration, proliferation, differentiation, and transcription. RHOA is expressed in the developing cardiac conduction system in chicken and mice. In early development, the entire sinus venosus...
2.
van den Berg C, Okawa S, Chuva de Sousa Lopes S, Van Iperen L, Passier R, Braam S, et al.
Development
. 2015 Jul;
142(18):3231-8.
PMID: 26209647
Differentiated derivatives of human pluripotent stem cells (hPSCs) are often considered immature because they resemble foetal cells more than adult, with hPSC-derived cardiomyocytes (hPSC-CMs) being no exception. Many functional features...
3.
Ribeiro M, Tertoolen L, Guadix J, Bellin M, Kosmidis G, DAniello C, et al.
Biomaterials
. 2015 Mar;
51:138-150.
PMID: 25771005
Cardiomyocytes from human pluripotent stem cells (hPSC-CM) have many potential applications in disease modelling and drug target discovery but their phenotypic similarity to early fetal stages of cardiac development limits...
4.
van Laake L, Passier R, Monshouwer-Kloots J, Verkleij A, Lips D, Freund C, et al.
Stem Cell Res
. 2009 Apr;
1(1):9-24.
PMID: 19383383
Regeneration of the myocardium by transplantation of cardiomyocytes is an emerging therapeutic strategy. Human embryonic stem cells (HESC) form cardiomyocytes readily but until recently at low efficiency, so that preclinical...
5.
Moore J, Spijker R, Martens A, De Boer T, Rook M, van der Heyden M, et al.
Int J Dev Biol
. 2004 Mar;
48(1):47-55.
PMID: 15005574
The clinical application of stem cell therapies is still limited by the ability to produce defined, differentiated cell populations in large numbers in culture. High throughput screens to identify factors...
6.
den Hertog J, van der Wijk T, Tertoolen L, Blanchetot C
Methods Enzymol
. 2003 Dec;
366:224-40.
PMID: 14674252
No abstract available.
7.
Blanchetot C, Tertoolen L, Overvoorde J, den Hertog J
J Biol Chem
. 2002 Oct;
277(49):47263-9.
PMID: 12376545
The presence of two protein-tyrosine phosphatase (PTP) domains is a striking feature in most transmembrane receptor PTPs (RPTPs). The generally inactive membrane-distal PTP domains (RPTP-D2s) bind and are proposed to...