Leo Swadling
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Explore the profile of Leo Swadling including associated specialties, affiliations and a list of published articles.
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50
Citations
2436
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Recent Articles
1.
Rubio R, Yavlinsky A, Escalera Zamudio M, Molinos-Albert L, Martin Perez C, Pradenas E, et al.
J Infect
. 2025 Jan;
90(2):106402.
PMID: 39746406
Objectives: We aimed to evaluate the adaptive immune responses cross-recognition of the hypermutated SARS-CoV-2 BA.2.86 variant and identify the determinants influencing this recognition. Methods: We measured BA.2.86 neutralizing antibodies and...
2.
Lindeboom R, Worlock K, Dratva L, Yoshida M, Scobie D, Wagstaffe H, et al.
Nature
. 2024 Aug;
632(8025):E3.
PMID: 39090314
No abstract available.
3.
Bosch M, Kallin N, Donakonda S, Zhang J, Wintersteller H, Hegenbarth S, et al.
Nature
. 2024 Jul;
631(8022):867-875.
PMID: 38987588
Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes. Here...
4.
Lindeboom R, Worlock K, Dratva L, Yoshida M, Scobie D, Wagstaffe H, et al.
Nature
. 2024 Jun;
631(8019):189-198.
PMID: 38898278
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited. Here in our SARS-CoV-2 human challenge...
5.
Diniz M, Maini M, Swadling L
Semin Immunol
. 2023 Aug;
70:101828.
PMID: 37651850
Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not...
6.
Altmann D, Reynolds C, Joy G, Otter A, Gibbons J, Pade C, et al.
Nat Commun
. 2023 Aug;
14(1):5139.
PMID: 37612310
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been...
7.
Wing P, Schmidt N, Peters R, Erdmann M, Brown R, Wang H, et al.
PLoS Pathog
. 2023 May;
19(5):e1011323.
PMID: 37134108
The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome....
8.
Swadling L, Maini M
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36901802
Despite the highly infectious nature of the SARS-CoV-2 virus, it is clear that some individuals with potential exposure, or even experimental challenge with the virus, resist developing a detectable infection....
9.
Pallett L, Swadling L, Diniz M, Maini A, Schwabenland M, Dalmau Gasull A, et al.
Nature
. 2023 Jan;
614(7947):334-342.
PMID: 36697826
The liver is bathed in bacterial products, including lipopolysaccharide transported from the intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent pathogens and tumours. The...
10.
Mazouz S, Salinas E, Bedard N, Filali A, Khedr O, Swadling L, et al.
PLoS Pathog
. 2022 Nov;
18(11):e1010968.
PMID: 36378682
Successive episodes of hepatitis C virus (HCV) infection represent a unique natural rechallenge experiment to define correlates of long-term protective immunity and inform vaccine development. We applied a systems immunology...