Lennard P Niles
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Explore the profile of Lennard P Niles including associated specialties, affiliations and a list of published articles.
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22
Citations
313
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Recent Articles
1.
Hartung E, Mukhtar S, Shah S, Niles L
Mol Biol Rep
. 2020 May;
47(6):4867-4873.
PMID: 32410138
The multiple physiological effects of the indoleamine melatonin, are mediated primarily by its two G protein-coupled MT and MT receptors. Treatment with histone deacetylase (HDAC) inhibitors, including valproic acid (VPA)...
2.
Bahna S, Niles L
Br J Pharmacol
. 2017 Oct;
175(16):3209-3219.
PMID: 28967098
Melatonin, the primary indoleamine hormone of the mammalian pineal gland, is known to have a plethora of neuroregulatory, neuroprotective and other properties. Melatonergic signalling is mediated by its two GPCRs,...
3.
Bahna S, Niles L
Eur Neuropsychopharmacol
. 2017 Jun;
27(8):828-832.
PMID: 28648552
We have reported that the anticonvulsant/mood stabilizer and histone deacetylase (HDAC) inhibitor valproate (VPA) induces expression of melatonin receptors both in vitro and in vivo, but the mechanisms involved were...
4.
Carriere C, Kang N, Niles L
Exp Toxicol Pathol
. 2016 Dec;
69(2):109-114.
PMID: 27986376
The pesticide rotenone has been shown to cause systemic inhibition of mitochondrial complex I activity, with consequent degeneration of dopamine neurons along the nigrostriatal pathway, as observed in Parkinson's disease...
5.
Kang N, Carriere C, Bahna S, Niles L
Brain Res
. 2016 Oct;
1652:89-96.
PMID: 27693415
The indoleamine hormone melatonin protects dopamine neurons in the rat nigrostriatal pathway following 6-hydroxydopamine lesioning, and an increase in striatal melatonin levels has been detected in this model of Parkinson's...
6.
Carriere C, Kang N, Niles L
Brain Res
. 2016 Jan;
1633:115-125.
PMID: 26740407
Parkinson's disease is a major neurodegenerative disorder which primarily involves the loss of dopaminergic neurons in the substantia nigra and related projections in the striatum. The pesticide/neurotoxin, rotenone, has been...
7.
Pan Y, Niles L
Mol Cell Endocrinol
. 2015 Jan;
402:57-63.
PMID: 25578604
We have shown that melatonin induces histone hyperacetylation in vitro and in vivo. To clarify the mechanisms involved, we have now investigated its effects on histone acetylation and signaling pathways...
8.
Bahna S, Sathiyapalan A, Foster J, Niles L
Neurosci Lett
. 2014 Jun;
576:84-7.
PMID: 24909617
We have reported that clinically relevant concentrations of valproic acid (VPA) upregulate the G protein-coupled melatonin MT1 receptor in rat C6 glioma cells, and both MT1 and MT2 receptors in...
9.
Almutawaa W, Kang N, Pan Y, Niles L
Basic Clin Pharmacol Toxicol
. 2014 Jan;
115(2):216-21.
PMID: 24460582
Valproic acid (VPA), a short-chain fatty acid, is used clinically as an anticonvulsant and mood stabilizer. Valproic acid also inhibits histone deacetylase activity, which is associated with histone hyperacetylation and...
10.
Niles L, Pan Y, Kang S, Lacoul A
Neurosci Lett
. 2013 Feb;
541:49-53.
PMID: 23416321
We have reported that melatonin induces histone hyperacetylation in mouse neural stem cells, suggesting an epigenetic role for this pleiotropic hormone. To support such a role, it is necessary to...