Leigh L van den Heuvel
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Explore the profile of Leigh L van den Heuvel including associated specialties, affiliations and a list of published articles.
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28
Citations
302
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Recent Articles
1.
Jansen Van Vuren E, van den Heuvel L, Hemmings S, Seedat S
J Psychiatr Res
. 2025 Jan;
182:338-346.
PMID: 39848101
Background: The pathophysiology of posttraumatic stress disorder (PTSD) involves dysregulation of stress-sensitive biological systems due to repeated trauma exposure, predisposing individuals to the development of cardiovascular disease (CVD). Allostatic load...
2.
Katrinli S, Wani A, Maihofer A, Ratanatharathorn A, Daskalakis N, Montalvo-Ortiz J, et al.
Genome Med
. 2024 Dec;
16(1):147.
PMID: 39696436
Background: The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the...
3.
OHare M, Swart P, Malan-Muller S, van den Heuvel L, Brocker E, Seedat S, et al.
Neuroimmunomodulation
. 2024 Nov;
32(1):1-15.
PMID: 39561720
Introduction: Common mental disorders, such as anxiety disorders, depression, and posttraumatic stress disorder (PTSD), present a substantial health and economic burden. The gut microbiome has been associated with these psychiatric...
4.
Katrinli S, Wani A, Maihofer A, Ratanatharathorn A, Daskalakis N, Montalvo-Ortiz J, et al.
medRxiv
. 2024 Jul;
PMID: 39072012
Background: The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the...
5.
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, et al.
Nat Genet
. 2024 Apr;
56(5):792-808.
PMID: 38637617
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed...
6.
Hendrikse C, Luckhoff H, Fouche J, van den Heuvel L, Emsley R, Seedat S, et al.
J Neurosci Res
. 2024 Feb;
102(2):e25308.
PMID: 38361421
Childhood trauma (CT) may influence brain white matter microstructure; however, few studies have examined the differential impact of distinct CT types on white matter microstructure in psychiatrically healthy adults living...
7.
Mesa-Vieira C, Didden C, Schomaker M, Mouton J, Folb N, van den Heuvel L, et al.
Epidemiol Psychiatr Sci
. 2024 Feb;
33:e5.
PMID: 38314538
Aims: Prior research, largely focused on US male veterans, indicates an increased risk of cardiovascular disease among individuals with post-traumatic stress disorder (PTSD). Data from other settings and populations are...
8.
Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, et al.
Mol Psychiatry
. 2024 Jan;
29(3):611-623.
PMID: 38195980
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that...
9.
Lekpeh G, Salie M, van den Heuvel L, Seedat S
S Afr J Psychiatr
. 2023 Dec;
29:2112.
PMID: 38059198
Background: Although literature globally indicates varied neurological and/or neuropsychiatric manifestations (NNM) and complications associated with coronavirus disease 2019 (COVID-19), information about NNM in infected hospitalised patients on the African continent...
10.
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, et al.
Neuropsychopharmacology
. 2023 Nov;
49(3):609-619.
PMID: 38017161
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between...