Leena Kainulainen
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Explore the profile of Leena Kainulainen including associated specialties, affiliations and a list of published articles.
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32
Citations
703
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Recent Articles
1.
Wahrmann S, Kainulainen L, Lempainen J, Kyto V
Acta Paediatr
. 2024 Dec;
PMID: 39736088
Aim: Studies on treating infections in children with 22q11.2 deletion syndrome (22q11.2DS) have been limited. We characterised inpatient infections and outpatient antibiotic treatment. Methods: Children born during 2005-2018 were eligible...
2.
Terasjarvi J, Kainulainen L, Peltola V, Mertsola J, Hakanen A, He Q
Int J Immunogenet
. 2024 May;
51(4):242-251.
PMID: 38706134
Toll-like receptors (TLRs) play an important role in innate immunity. Previous studies have shown that single nucleotide polymorphisms (SNPs) in the genes coding for these innate immune molecules can affect...
3.
Vallee T, Glasmacher J, Buchner H, Arkwright P, Behrends U, Bondarenko A, et al.
Blood
. 2024 Apr;
143(24):2504-2516.
PMID: 38579284
Wiskott-Aldrich syndrome (WAS) is a multifaceted monogenic disorder with a broad disease spectrum and variable disease severity and a variety of treatment options including allogeneic hematopoietic stem cell transplantation (HSCT)...
4.
Pello E, Kainulainen L, Vakkilainen M, Klemetti P, Taskinen M, Makitie O, et al.
J Allergy Clin Immunol Glob
. 2024 Jan;
3(1):100190.
PMID: 38187867
Background: Cartilage-hair hypoplasia (CHH) is a syndromic inborn error of immunity caused by variants in the gene. Disease manifestations vary, and their ability to predict outcome is uncertain. The optimal...
5.
Hurme A, Jalkanen P, Marttila-Vaara M, Heroum J, Jokinen H, Vara S, et al.
Front Immunol
. 2023 May;
14:1146500.
PMID: 37234151
Primary antibody deficiencies, such as common variable immunodeficiency (CVID), are heterogenous disease entities consisting of primary hypogammaglobulinemia and impaired antibody responses to vaccination and natural infection. CVID is the most...
6.
Wahrmann S, Kainulainen L, Kyto V, Lempainen J
Acta Paediatr
. 2023 Mar;
112(6):1312-1318.
PMID: 36867048
Aim: The aim of the study was to describe the clinical manifestations of 22q11.2 deletion syndrome patients in the Finnish paediatric population. Methods: Nationwide registry data including all diagnoses and...
7.
Helenius K, Ojala L, Kainulainen L, Peltonen S, Hietala M, Pohjola P, et al.
Eur J Med Genet
. 2023 Mar;
66(5):104735.
PMID: 36863510
Pathogenic variants in the transcription factor TP63 gene cause a variety of clinical phenotypes, such as ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome and ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome. Historically, TP63-related phenotypes have been...
8.
Masle-Farquhar E, Jackson K, Peters T, Al-Eryani G, Singh M, Payne K, et al.
Immunity
. 2022 Nov;
55(12):2386-2404.e8.
PMID: 36446385
The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate...
9.
Leiding J, Vogel T, Santarlas V, Mhaskar R, Smith M, Carisey A, et al.
J Allergy Clin Immunol
. 2022 Oct;
151(4):1081-1095.
PMID: 36228738
Background: In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-of-function (GOF) mutations were first described to cause a novel multisystem disease of early-onset lymphoproliferation and autoimmunity. Objective:...
10.
Tahtinen P, Ivaska L, Jalkanen P, Kakkola L, Kainulainen L, Hytonen J, et al.
Infect Dis (Lond)
. 2022 Jan;
54(6):448-454.
PMID: 35045784
Background: Health care workers are at risk of acquiring SARS-CoV-2 infection. Our aim was to study the prevalence of SARS-CoV-2 nucleoprotein and spike protein specific antibodies in health care workers...