Leemor Joshua-Tor
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Explore the profile of Leemor Joshua-Tor including associated specialties, affiliations and a list of published articles.
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71
Citations
6080
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Recent Articles
1.
Garg A, On K, Xiao Y, Elkayam E, Cifani P, David Y, et al.
Nat Commun
. 2025 Jan;
16(1):941.
PMID: 39843453
Glycation, a non-enzymatic post-translational modification occurring on proteins, can be actively reversed via site-specific phosphorylation of the fructose-lysine moiety by FN3K kinase, to impact the cellular function of the target...
2.
Garg A, Shang R, Cvetanovic T, Lai E, Joshua-Tor L
Mol Cell
. 2024 Oct;
84(21):4175-4190.e6.
PMID: 39368465
MicroRNA (miRNA) biogenesis is initiated upon cleavage of a primary miRNA (pri-miRNA) hairpin by the Microprocessor (MP), composed of the Drosha RNase III enzyme and its partner DGCR8. Multiple pri-miRNA...
3.
Garg A, On K, Xiao Y, Elkayam E, Cifani P, David Y, et al.
bioRxiv
. 2024 Aug;
PMID: 39149269
Glycation, a non-enzymatic post-translational modification occurring on proteins, can be actively reversed via site-specific phosphorylation of the fructose-lysine moiety by FN3K kinase, to impact the cellular function of target protein....
4.
Garg A, Shang R, Cvetanovic T, Lai E, Joshua-Tor L
bioRxiv
. 2024 May;
PMID: 38766155
miRNA biogenesis is initiated upon cleavage of a primary miRNA (pri-miRNA) hairpin by the Microprocessor (MP), composed of the Drosha RNase III enzyme and its partner DGCR8. Multiple pri-miRNA sequence...
5.
Segovia D, Adams D, Hoffman N, Safaric Tepes P, Wee T, Cifani P, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2322974121.
PMID: 38743621
SRSF1 is the founding member of the SR protein family. It is required-interchangeably with other SR proteins-for pre-mRNA splicing in vitro, and it regulates various alternative splicing events. Dysregulation of...
6.
Kotagama K, Grimme A, Braviner L, Yang B, Sakhawala R, Yu G, et al.
Nucleic Acids Res
. 2024 Mar;
52(9):4985-5001.
PMID: 38471816
Many microRNA (miRNA)-guided Argonaute proteins can cleave RNA ('slicing'), even though miRNA-mediated target repression is generally cleavage-independent. Here we use Caenorhabditis elegans to examine the role of catalytic residues of...
7.
Qian Z, Song D, Ipsaro J, Bautista C, Joshua-Tor L, Yeh J, et al.
Genes Dev
. 2023 Sep;
37(15-16):743-759.
PMID: 37669874
Protein tyrosine phosphatases (PTPs) are critical regulators of signal transduction but have yet to be exploited fully for drug development. Receptor protein tyrosine phosphatase δ (RPTPδ/PTPRD) has been shown to...
8.
Kinney B, Sahu S, Stec N, Hills-Muckey K, Adams D, Wang J, et al.
Dev Cell
. 2023 Aug;
58(22):2563-2579.e8.
PMID: 37643611
Development relies on the exquisite control of both the timing and the levels of gene expression to achieve robust developmental transitions. How cis- and trans-acting factors control both aspects simultaneously...
9.
Lee S, Adams D, Ipsaro J, Cahn J, Lynn J, Kim H, et al.
Cell
. 2023 Aug;
186(19):4100-4116.e15.
PMID: 37643610
Nucleosomes block access to DNA methyltransferase, unless they are remodeled by DECREASE in DNA METHYLATION 1 (DDM1), a Snf2-like master regulator of epigenetic inheritance. We show that DDM1 promotes replacement...
10.
Lee S, Adams D, Ipsaro J, Cahn J, Lynn J, Kim H, et al.
bioRxiv
. 2023 Jul;
PMID: 37503143
Epigenetic inheritance refers to the faithful replication of DNA methylation and histone modification independent of DNA sequence. Nucleosomes block access to DNA methyltransferases, unless they are remodeled by DECREASE IN...