Lee Timms
Overview
Explore the profile of Lee Timms including associated specialties, affiliations and a list of published articles.
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17
Citations
4219
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0
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Recent Articles
1.
Zaidi S, Harrison T, Phipps A, Steinfelder R, Trinh Q, Qu C, et al.
Nat Commun
. 2020 Jul;
11(1):3644.
PMID: 32686686
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows...
2.
Houlahan K, Shiah Y, Gusev A, Yuan J, Ahmed M, Shetty A, et al.
Nat Med
. 2019 Oct;
25(10):1615-1626.
PMID: 31591588
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms...
3.
Abelson S, Collord G, Ng S, Weissbrod O, Mendelson Cohen N, Niemeyer E, et al.
Nature
. 2018 Jul;
559(7714):400-404.
PMID: 29988082
The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually...
4.
Aung K, Fischer S, Denroche R, Jang G, Dodd A, Creighton S, et al.
Clin Cancer Res
. 2017 Dec;
24(6):1344-1354.
PMID: 29288237
To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational and transcriptional features for better treatment selection. Patients with...
5.
Fraser M, Sabelnykova V, Yamaguchi T, Heisler L, Livingstone J, Huang V, et al.
Nature
. 2017 Jan;
541(7637):359-364.
PMID: 28068672
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences and...
6.
Taylor R, Fraser M, Livingstone J, Espiritu S, Thorne H, Huang V, et al.
Nat Commun
. 2017 Jan;
8:13671.
PMID: 28067867
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression,...
7.
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson G, Connor A, et al.
Nature
. 2016 Nov;
542(7639):124.
PMID: 27851734
No abstract available.
8.
Connor A, Denroche R, Jang G, Timms L, Kalimuthu S, Selander I, et al.
JAMA Oncol
. 2016 Oct;
3(6):774-783.
PMID: 27768182
Importance: Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. Advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data...
9.
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson G, Connor A, et al.
Nature
. 2016 Oct;
538(7625):378-382.
PMID: 27732578
Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor...
10.
Denroche R, Mullen L, Timms L, Beck T, Yung C, Stein L, et al.
BMC Res Notes
. 2015 Dec;
8:823.
PMID: 26708082
Background: Accurate detection of somatic single nucleotide variants and small insertions and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging task. Tumour samples are often contaminated with...