Lee L Rubin
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Explore the profile of Lee L Rubin including associated specialties, affiliations and a list of published articles.
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100
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7323
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Recent Articles
11.
Ximerakis M, Holton K, Giadone R, Ozek C, Saxena M, Santiago S, et al.
Nat Aging
. 2023 Apr;
3(3):327-345.
PMID: 37118429
Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of...
12.
Berryer M, Rizki G, Nathanson A, Klein J, Trendafilova D, Susco S, et al.
Elife
. 2023 Apr;
12.
PMID: 37083703
Resolving fundamental molecular and functional processes underlying human synaptic development is crucial for understanding normal brain function as well as dysfunction in disease. Based upon increasing evidence of species-divergent features...
13.
Neel D, Basu H, Gunner G, Bergstresser M, Giadone R, Chung H, et al.
Neuron
. 2023 Mar;
111(8):1222-1240.e9.
PMID: 36917977
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS)...
14.
Rapino F, Natoli T, Limone F, OConnor E, Blank J, Tegtmeyer M, et al.
Stem Cell Reports
. 2022 Dec;
18(1):237-253.
PMID: 36563689
In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that...
15.
Spetz J, Florido M, Fraser C, Qin X, Choiniere J, Yu S, et al.
Sci Adv
. 2022 Nov;
8(45):eabn6579.
PMID: 36351019
Although major organ toxicities frequently arise in patients treated with cytotoxic or targeted cancer therapies, the mechanisms that drive them are poorly understood. Here, we report that vascular endothelial cells...
16.
Cronin S, Rao S, Tejada M, Lenfers Turnes B, Licht-Mayer S, Omura T, et al.
Sci Transl Med
. 2022 Aug;
14(660):eabj1531.
PMID: 36044597
Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic...
17.
Pediaditakis I, Kodella K, Manatakis D, Le C, Barthakur S, Sorets A, et al.
iScience
. 2022 Aug;
25(8):104813.
PMID: 35982785
Species differences in brain and blood-brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases. Here, we present...
18.
Martinez-Pastor B, Silveira G, Clarke T, Chung D, Gu Y, Cosentino C, et al.
Cell Rep
. 2021 Dec;
37(13):110176.
PMID: 34965416
Repair of genetic damage is coordinated in the context of chromatin, so cells dynamically modulate accessibility at DNA breaks for the recruitment of DNA damage response (DDR) factors. The identification...
19.
Pediaditakis I, Kodella K, Manatakis D, Le C, Hinojosa C, Tien-Street W, et al.
Nat Commun
. 2021 Oct;
12(1):5907.
PMID: 34625559
Parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical evidence and in vitro...
20.
Cheng Y, Snavely A, Barrett L, Zhang X, Herman C, Frost D, et al.
Cell Rep
. 2021 Sep;
36(10):109666.
PMID: 34496254
Although axonal damage induces rapid changes in gene expression in primary sensory neurons, it remains unclear how this process is initiated. The transcription factor ATF3, one of the earliest genes...