Lee Frego
Overview
Explore the profile of Lee Frego including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
224
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0
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Recent Articles
1.
Mitrovic S, Demalgiriya-Gamage C, Winter L, Kiechle T, Ebenhoch R, Neubauer H, et al.
Commun Biol
. 2024 Nov;
7(1):1588.
PMID: 39609618
GOLD domain seven-transmembrane helix (GOST) proteins form a new protein family involved in trafficking of membrane-associated cargo. They share a characteristic extracellular/luminal Golgi-dynamics (GOLD) domain, possibly responsible for ligand recognition....
2.
Wu H, Crames M, Wei Y, Liu D, Gueneva-Boucheva K, Son I, et al.
J Pharm Sci
. 2022 Jun;
111(9):2411-2421.
PMID: 35760121
Monoclonal antibodies, particularly IgGs and Ig-based molecules, are a well-established and growing class of biotherapeutic drugs. In order to improve efficacy, potency and pharmacokinetics of these therapeutic drugs, pharmaceutical industries...
3.
Zettl M, Wurm M, Schaaf O, Mostbock S, Tirapu I, Apfler I, et al.
Oncoimmunology
. 2022 Jun;
11(1):2080328.
PMID: 35756842
Upregulation of inhibitory receptors, such as lymphocyte activation gene-3 (LAG-3), may limit the antitumor activity of therapeutic antibodies targeting the programmed cell death protein-1 (PD-1) pathway. We describe the binding...
4.
Wu H, Ralph K, Sepuldeva E, Hansen G, Li H, Huang Z, et al.
Int J Pharm
. 2021 Oct;
609:121162.
PMID: 34624444
Antibodies targeting the CD40-CD40L pathway have great potential for treating autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus (SLE), lupus nephritis (LN), and inflammatory bowel diseases (IBD). However, in addition...
5.
Ebenhoch R, Akhdar A, Reboll M, Korf-Klingebiel M, Gupta P, Armstrong J, et al.
Nat Commun
. 2019 Nov;
10(1):5379.
PMID: 31772377
Myeloid-derived growth factor (MYDGF) is a paracrine-acting protein that is produced by bone marrow-derived monocytes and macrophages to protect and repair the heart after myocardial infarction (MI). This effect can...
6.
Venkataramani S, Low S, Weigle B, Dutcher D, Jerath K, Menzenski M, et al.
Biochem Biophys Res Commun
. 2018 Aug;
504(1):19-24.
PMID: 30126632
Patients with severe Th2 type asthma often have a steroid resistant phenotype and are prone to acute exacerbations. Current novel therapies have only marginal therapeutic effects. One of the hypotheses...
7.
Ganesan R, Raymond E, Mennerich D, Woska Jr J, Caviness G, Grimaldi C, et al.
MAbs
. 2017 Jul;
9(7):1143-1154.
PMID: 28726542
Deficiency of interleukin (IL)-36 receptor antagonist (DITRA) syndrome is a rare autosomal recessive disease caused by mutations in IL36RN. IL-36R is a cell surface receptor and a member of the...
8.
Yang D, Frego L, Lasaro M, Truncali K, Kroe-Barrett R, Singh S
J Biol Chem
. 2016 Jun;
291(31):16361-74.
PMID: 27288409
To determine the effectiveness of immunization strategies used in therapeutic antibody or vaccine development, it is critical to assess the quality of immunization-induced polyclonal antibody responses. Here, we developed a...
9.
Mariana Margarit S, Davidson W, Frego L, Stebbins C
Structure
. 2006 Aug;
14(8):1219-29.
PMID: 16905096
Salmonella spp. require the ADP-ribosyltransferase activity of the SpvB protein for intracellular growth and systemic virulence. SpvB covalently modifies actin, causing cytoskeletal disruption and apoptosis. We report here the crystal...
10.
Frego L, Gautschi E, Martin L, Davidson W
Rapid Commun Mass Spectrom
. 2006 Jul;
20(16):2478-82.
PMID: 16862625
Recently, a hydrogen/deuterium exchange method termed SUPREX (Stability of Unpurified Proteins from Rates of hydrogen/deuterium EXchange), capable of measuring protein/ligand binding constants, which utilizes matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS),...