Leah C Jimmerson
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Explore the profile of Leah C Jimmerson including associated specialties, affiliations and a list of published articles.
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9
Citations
94
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Recent Articles
1.
Brooks K, Castillo-Mancilla J, Morrow M, MaWhinney S, Rowan S, Wyles D, et al.
J Antimicrob Chemother
. 2022 Feb;
77(5):1396-1403.
PMID: 35194648
Background: Sofosbuvir is converted to its active form, 007 triphosphate (007-TP), within cells. To date, the association between treatment adherence and 007-TP in dried blood spots (DBS) and factors that...
2.
Mumtaz N, Jimmerson L, Bushman L, Kiser J, Aron G, Reusken C, et al.
Antiviral Res
. 2017 Sep;
146:161-163.
PMID: 28912011
The recent epidemic of Zika virus (ZIKV) in the Americas and its association with fetal and neurological complications has shown the need to develop a treatment. Repurposing of drugs that...
3.
Jimmerson L, Clayton C, MaWhinney S, Meissner E, Sims Z, Kottilil S, et al.
Antiviral Res
. 2016 Dec;
138:79-85.
PMID: 27956135
Ribavirin (RBV), a purine analog, causes hemolytic anemia in some patients. In vitro, anemia appears to result from depletion of endogenous purines, but there are limited data in vivo. Single...
4.
Jimmerson L, Bushman L, Ray M, Anderson P, Kiser J
Pharm Res
. 2016 Sep;
34(1):73-83.
PMID: 27633886
Purpose: To develop and validate a method for the simultaneous measurement of adenosine, guanosine, and inosine derived from mono (MP) and triphosphate (TP) forms in peripheral blood mononuclear cells (PBMCs),...
5.
Jimmerson L, Urban T, Truesdale A, Baouchi-Mokrane F, Kottilil S, Meissner E, et al.
J Clin Pharmacol
. 2016 Jun;
57(1):118-124.
PMID: 27349952
Individuals with lower inosine triphosphatase (ITPA) enzyme activity have a reduced likelihood of experiencing hemolytic anemia during hepatitis C virus (HCV) treatment containing ribavirin (RBV). Because ITPA degrades purines and...
6.
Rower J, Jimmerson L, Chen X, Zheng J, Hodara A, Bushman L, et al.
Antimicrob Agents Chemother
. 2015 Sep;
59(12):7671-9.
PMID: 26416874
Sofosbuvir (SOF) is a highly efficacious and well-tolerated uridine nucleotide analog that inhibits the hepatitis C virus (HCV) NS5B polymerase enzyme. SOF is administered as a prodrug, which undergoes intracellular...
7.
Rower J, Meissner E, Jimmerson L, Osinusi A, Sims Z, Petersen T, et al.
J Antimicrob Chemother
. 2015 May;
70(8):2322-9.
PMID: 25971261
Objectives: Ribavirin concentrations may impact hepatitis C virus (HCV) treatment outcome. We modelled ribavirin serum and intracellular ribavirin monophosphate (RBV-MP) and ribavirin triphosphate (RBV-TP) pharmacokinetics in red blood cells (RBC)...
8.
Jimmerson L, Ray M, Bushman L, Anderson P, Klein B, Rower J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2015 Jan;
978-979:163-72.
PMID: 25555148
Ribavirin (RBV) is a nucleoside analog used to treat a variety of DNA and RNA viruses. RBV undergoes intracellular phosphorylation to a mono- (MP), di- (DP), and triphosphate (TP). The...
9.
Jimmerson L, Zheng J, Bushman L, MacBrayne C, Anderson P, Kiser J
J Chromatogr B Analyt Technol Biomed Life Sci
. 2013 Dec;
944:18-24.
PMID: 24291608
Efficient, inexpensive and sensitive assays for the measurement of drugs are of interest for pharmacokinetic and pharmacodynamics (PK-PD) analysis. Dried blood spots (DBS) are a unique bioanaltyical matrix with the...