Lea Brys
Overview
Explore the profile of Lea Brys including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1466
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Recent Articles
1.
Stijlemans B, De Baetselier P, Van Molle I, Lecordier L, Hendrickx E, Romao E, et al.
Nat Commun
. 2024 Feb;
15(1):1779.
PMID: 38413606
Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is characterized by the manipulation of the host's immune response to ensure parasite invasion and persistence. Uncovering...
2.
Hu Y, Romao E, Vincke C, Brys L, Elkrim Y, Vandevenne M, et al.
Int J Mol Sci
. 2021 Nov;
22(22).
PMID: 34830219
Uncontrolled growth of solid tumors will result in a hallmark hypoxic condition, whereby the key transcriptional regulator of hypoxia inducible factor-1α (HIF-1α) will be stabilized to activate the transcription of...
3.
Stijlemans B, Korf H, De Baetselier P, Brys L, Van Ginderachter J, Magez S, et al.
PLoS Pathog
. 2020 Feb;
16(2):e1008170.
PMID: 32012211
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T. congolense, causing...
4.
Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx Y, Schoonooghe S, et al.
FASEB J
. 2018 Feb;
32(6):3411-3422.
PMID: 29401625
Sepsis-leading to septic shock-is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role...
5.
Stijlemans B, Brys L, Korf H, Bieniasz-Krzywiec P, Sparkes A, Vansintjan L, et al.
PLoS Pathog
. 2016 Sep;
12(9):e1005862.
PMID: 27632207
Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent the major constraint in livestock production, with anemia as...
6.
Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, et al.
Cancer Res
. 2015 Nov;
76(1):35-42.
PMID: 26573801
Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate from Ly6C(hi) monocytes. However, the mechanisms regulating the abundance and phenotype of...
7.
Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, et al.
PLoS Pathog
. 2014 Sep;
10(9):e1004414.
PMID: 25255103
African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response,...
8.
Lo A, Moonens K, De Kerpel M, Brys L, Pardon E, Remaut H, et al.
J Biol Chem
. 2014 Jul;
289(36):25374-81.
PMID: 25053417
Shiga toxin Stx2e is the major known agent that causes edema disease in newly weaned pigs. This severe disease is characterized by neurological disorders, hemorrhagic lesions, and frequent fatal outcomes....
9.
Roelants K, Fry B, Ye L, Stijlemans B, Brys L, Kok P, et al.
PLoS Genet
. 2013 Aug;
9(8):e1003662.
PMID: 23935531
The skin secretion of many amphibians contains an arsenal of bioactive molecules, including hormone-like peptides (HLPs) acting as defense toxins against predators, and antimicrobial peptides (AMPs) providing protection against infectious...
10.
Van den Bossche J, Lamers W, Koehler E, Geuns J, Alhonen L, Uimari A, et al.
J Leukoc Biol
. 2012 Mar;
91(5):685-99.
PMID: 22416259
In macrophages, basal polyamine (putrescine, spermidine, and spermine) levels are relatively low but are increased upon IL-4 stimulation. This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and...