Lea Barthel
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Explore the profile of Lea Barthel including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1664
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Recent Articles
1.
Barthel L, Pettemeridi S, Nebras A, Schnaidt H, Fahland K, Vormwald L, et al.
Front Cell Dev Biol
. 2024 Oct;
12:1434168.
PMID: 39445331
Spt4 and Spt5 form the DRB sensitivity inducing factor (DSIF) complex that regulates transcription elongation at multiple steps including promotor-proximal pausing, processivity and termination. Although this implicated a general role...
2.
Saleh L, Amer L, Thompson B, Danhorn T, Knapp J, Gibbings S, et al.
Adv Healthc Mater
. 2021 Dec;
11(9):e2102209.
PMID: 34967497
Poly(ethylene glycol) (PEG) hydrogels hold promise for in vivo applications but induce a foreign body response (FBR). While macrophages are key in the FBR, many questions remain. This study investigates...
3.
Mohning M, Thomas S, Barthel L, Mould K, McCubbrey A, Frasch S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2017 Sep;
314(1):L69-L82.
PMID: 28935638
Microparticles are a newly recognized class of mediators in the pathophysiology of lung inflammation and injury, but little is known about the factors that regulate their accumulation and clearance. The...
4.
Neudecker V, Brodsky K, Clambey E, Schmidt E, Packard T, Davenport B, et al.
Sci Transl Med
. 2017 Sep;
9(408).
PMID: 28931657
Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung...
5.
McCubbrey A, Barthel L, Mohning M, Redente E, Mould K, Thomas S, et al.
Am J Respir Cell Mol Biol
. 2017 Aug;
58(1):66-78.
PMID: 28850249
Idiopathic pulmonary fibrosis is a progressive lung disease with complex pathophysiology and fatal prognosis. Macrophages (MΦ) contribute to the development of lung fibrosis; however, the underlying mechanisms and specific MΦ...
6.
Kumar R, Mickael C, Kassa B, Gebreab L, Robinson J, Koyanagi D, et al.
Nat Commun
. 2017 May;
8:15494.
PMID: 28555642
Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, TGF-β blockade can...
7.
Mould K, Barthel L, Mohning M, Thomas S, McCubbrey A, Danhorn T, et al.
Am J Respir Cell Mol Biol
. 2017 Apr;
57(3):294-306.
PMID: 28421818
Two populations of alveolar macrophages (AMs) coexist in the inflamed lung: resident AMs that arise during embryogenesis, and recruited AMs that originate postnatally from circulating monocytes. The objective of this...
8.
McCubbrey A, Barthel L, Mould K, Mohning M, Redente E, Janssen W
Am J Physiol Lung Cell Mol Physiol
. 2016 May;
311(1):L87-L100.
PMID: 27190063
During homeostasis two distinct macrophage (Mø) populations inhabit the lungs: tissue Mø (often called interstitial Mø) and resident alveolar Mø (resAMø). During acute lung inflammation, monocytes from the circulation migrate...
9.
Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia A, et al.
Am J Respir Crit Care Med
. 2015 Jul;
192(8):998-1008.
PMID: 26192556
Rationale: The etiology of schistosomiasis-associated pulmonary arterial hypertension (PAH), a major cause of PAH worldwide, is poorly understood. Schistosoma mansoni exposure results in prototypical type-2 inflammation. Furthermore, transforming growth factor...
10.
Ghosh M, Dwyer-Nield L, Kwon J, Barthel L, Janssen W, Merrick D, et al.
PLoS One
. 2015 Apr;
10(4):e0122823.
PMID: 25860262
Squamous cell lung cancer (SCC) is the second leading cause of lung cancer death in the US and has a 5-year survival rate of only 16%. Histological changes in the...