Lawrence C Thompson
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Explore the profile of Lawrence C Thompson including associated specialties, affiliations and a list of published articles.
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10
Citations
95
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Recent Articles
1.
Powers T, Mullins E, Zhang K, Binder J, Friese O, Runnels H, et al.
Front Bioeng Biotechnol
. 2022 Apr;
10:753481.
PMID: 35449595
Physicochemical tests represent important tools for the analytical control strategy of biotherapeutics. For adenoviral modalities, anion-exchange high performance liquid chromatography (AEX-HPLC) represents an important methodology, as it is able to...
2.
Mullins E, Powers T, Zobel J, Clawson K, Barnes L, Draper B, et al.
Front Bioeng Biotechnol
. 2021 Nov;
9:753480.
PMID: 34805110
We observed differential infectivity and product yield between two recombinant chimpanzee adenovirus C68 constructs whose primary difference was genome length. To determine a possible reason for this outcome, we characterized...
3.
Bae H, Tadie J, Jiang S, Park D, Bell C, Thompson L, et al.
J Immunol
. 2013 Jan;
190(5):2273-81.
PMID: 23345331
Effective removal of apoptotic cells, particularly apoptotic neutrophils, is essential for the successful resolution of acute inflammatory conditions. In these experiments, we found that whereas interaction between vitronectin and integrins...
4.
Bae H, Zmijewski J, Deshane J, Zhi D, Thompson L, Peterson C, et al.
Am J Respir Cell Mol Biol
. 2012 Jan;
46(6):790-6.
PMID: 22281987
Vitronectin is present in large concentrations in serum and the extracellular matrix. Although vitronectin is known to modulate neutrophil adhesion and chemotaxis, and to contribute to neutrophil-associated proinflammatory processes, a...
5.
Jensen J, Thompson L, Bucci J, Nissen P, Gettins P, Peterson C, et al.
J Biol Chem
. 2011 Jun;
286(34):29709-17.
PMID: 21697084
The serpin plasminogen activator inhibitor-1 (PAI-1) is a crucial regulator in fibrinolysis and tissue remodeling. PAI-1 has been associated with several pathological conditions and is a validated prognostic marker in...
6.
Thompson L, Goswami S, Peterson C
Protein Sci
. 2011 Feb;
20(2):366-78.
PMID: 21280128
Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. The lifespan of the active form of PAI-1 is modulated via interaction with...
7.
Thompson L, Goswami S, Ginsberg D, Day D, Verhamme I, Peterson C
Protein Sci
. 2011 Feb;
20(2):353-65.
PMID: 21280127
Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. Under physiological conditions, half of the inhibitor transitions to a latent state within...
8.
Thompson L, Ladner J, Codreanu S, Harp J, Gilliland G, Armstrong R
Biochemistry
. 2007 May;
46(23):6710-22.
PMID: 17508726
The enzyme 2-hydroxychromene-2-carboxylic acid (HCCA) isomerase catalyzes the glutathione (GSH)-dependent interconversion (Keq = 1.5) of HCCA and trans-o-hydroxybenzylidene pyruvic acid (tHBPA) in the naphthalene catabolic pathway of Pseudomonas putida. The...
9.
Thompson L, Walters J, Burke J, Parsons J, Armstrong R, Dirr H
Biochemistry
. 2006 Feb;
45(7):2267-73.
PMID: 16475815
Canonical glutathione (GSH) transferases are dimeric proteins with subunits composed of an N-terminal GSH binding region (domain 1) and a C-terminal helical region (domain 2). The stabilities of several GSH...
10.
Codreanu S, Thompson L, Hachey D, Dirr H, Armstrong R
Biochemistry
. 2005 Aug;
44(31):10605-12.
PMID: 16060669
Mammalian glutathione (GSH) transferases are dimeric proteins, many of which share a common hydrophobic interaction motif that is important for dimer stability. In the rGSTM1-1 enzyme this motif involves the...