Lawrence C Sincich
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Explore the profile of Lawrence C Sincich including associated specialties, affiliations and a list of published articles.
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28
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1266
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Recent Articles
1.
Meadway A, McKeown A, Samuels B, Sincich L
Ophthalmic Res
. 2020 Jan;
63(4):383-391.
PMID: 31910417
Introduction: Microscopic details about retinal conditions can provide insight into pathological mechanisms, but these are ordinarily difficult to obtain in situ. We demonstrate how high-resolution imaging and optical modeling can...
2.
Meadway A, Sincich L
Biomed Opt Express
. 2019 Dec;
10(12):6531-6554.
PMID: 31853415
In several modes of retinal imaging, the primary means of visualizing cone photoreceptors is from reflected light. Understanding how such images are formed, particularly when adaptive optics techniques are used,...
3.
Meadway A, Sincich L
Biomed Opt Express
. 2018 Nov;
9(11):5543-5565.
PMID: 30460146
The light capturing properties of cone photoreceptors create the elementary signals that form the basis of vision. Variation in the amplitude of individual cone signals has been found physiologically as...
4.
Tuten W, Harmening W, Sabesan R, Roorda A, Sincich L
J Neurosci
. 2017 Sep;
37(39):9498-9509.
PMID: 28871030
A remarkable feature of human vision is that the retina and brain have evolved circuitry to extract useful spatial and spectral information from signals originating in a photoreceptor mosaic with...
5.
Marcos S, Werner J, Burns S, Merigan W, Artal P, Atchison D, et al.
Vision Res
. 2017 Feb;
132:3-33.
PMID: 28212982
Adaptive optics is a relatively new field, yet it is spreading rapidly and allows new questions to be asked about how the visual system is organized. The editors of this...
6.
Bruce K, Harmening W, Langston B, Tuten W, Roorda A, Sincich L
Invest Ophthalmol Vis Sci
. 2015 Jul;
56(8):4431-8.
PMID: 26193919
Purpose: To determine the light sensitivity of poorly reflective cones observed in retinas of normal subjects, and to establish a relationship between cone reflectivity and perceptual threshold. Methods: Five subjects...
7.
Harmening W, Tuten W, Roorda A, Sincich L
J Neurosci
. 2014 Apr;
34(16):5667-77.
PMID: 24741057
In humans, experimental access to single sensory receptors is difficult to achieve, yet it is crucial for learning how the signals arising from each receptor are transformed into perception. By...
8.
Adams D, Economides J, Sincich L, Horton J
J Neurosci
. 2013 Mar;
33(9):3752-9.
PMID: 23447587
When an eye becomes deviated in early childhood, a person does not experience double vision, although the globes are aimed at different targets. The extra image is prevented from reaching...
9.
Harmening W, Tiruveedhula P, Roorda A, Sincich L
Biomed Opt Express
. 2012 Oct;
3(9):2066-77.
PMID: 23024901
A special challenge arises when pursuing multi-wavelength imaging of retinal tissue in vivo, because the eye's optics must be used as the main focusing elements, and they introduce significant chromatic...
10.
Sincich L, Jocson C, Horton J
J Neurosci
. 2012 Feb;
32(8):2648-56.
PMID: 22357849
The mechanism of amblyopia in children with congenital cataract is not understood fully, but studies in macaques have shown that geniculate synapses are lost in striate cortex (V1). To search...