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Lawrence B Schwartz

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Articles 121
Citations 3724
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Recent Articles
1.
Valent P, Hartmann K, Hoermann G, Reiter A, Alvarez-Twose I, Brockow K, et al.
J Allergy Clin Immunol Pract . 2024 Aug; 12(12):3250-3260.e5. PMID: 39216803
Mastocytosis is a clonal myeloid disorder defined by an increase and accumulation of mast cells (MCs) in one or multiple organ systems. The complex pathology of mastocytosis results in variable...
2.
Khalid M, Zektser E, Chu E, Li M, Utoh J, Ryan P, et al.
J Allergy Clin Immunol . 2024 Mar; 153(6):1634-1646. PMID: 38460680
Background: Systemic allergic reactions (sARs) following coronavirus disease 2019 (COVID-19) mRNA vaccines were initially reported at a higher rate than after traditional vaccines. Objective: We aimed to evaluate the safety...
3.
Haque T, Taruselli M, Kee S, Dailey J, Pondicherry N, Gajewski-Kurdziel P, et al.
Sci Signal . 2023 Sep; 16(802):eabc9089. PMID: 37699080
There is a clinical need for new treatment options addressing allergic disease. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that have anti-inflammatory properties. We tested the effects...
4.
Valent P, Hoermann G, Bonadonna P, Hartmann K, Sperr W, Broesby-Olsen S, et al.
J Allergy Clin Immunol Pract . 2023 Aug; 11(10):3010-3020. PMID: 37572755
Physiological levels of basal serum tryptase vary among healthy individuals, depending on the numbers of mast cells, basal secretion rate, copy numbers of the TPSAB1 gene encoding alpha tryptase, and...
5.
Dailey J, Kee S, Tharakan A, Kazi A, Burchett J, Kolawole E, et al.
J Immunol . 2023 Jul; 211(4):527-538. PMID: 37449905
IgE-mediated mast cell activation is a driving force in allergic disease in need of novel interventions. Statins, long used to lower serum cholesterol, have been shown in multiple large-cohort studies...
6.
Chovanec J, Tunc I, Hughes J, Halstead J, Mateja A, Liu Y, et al.
Blood Adv . 2022 Sep; 7(9):1796-1810. PMID: 36170795
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where basal serum tryptase (BST) levels >20 ng/mL are a minor...
7.
Gotlib J, Schwaab J, Shomali W, George T, Radia D, Castells M, et al.
J Allergy Clin Immunol Pract . 2022 Jun; 10(8):2025-2038.e1. PMID: 35724948
Advanced systemic mastocytosis (AdvSM) is characterized by the presence of KIT D816V and other somatic mutations (eg, in SRSF2, ASXL1, and RUNX1) in 95% and 60% to 70% of patients,...
8.
Valent P, Hartmann K, Schwaab J, Alvarez-Twose I, Brockow K, Bonadonna P, et al.
J Allergy Clin Immunol Pract . 2022 Mar; 10(8):1999-2012.e6. PMID: 35342031
Mastocytosis is a myeloid neoplasm defined by expansion and focal accumulation of clonal mast cells (MCs) in one or more organs. The disease exhibits a complex pathology and may be...
9.
Valent P, Akin C, Hartmann K, Alvarez-Twose I, Brockow K, Hermine O, et al.
Hemasphere . 2021 Dec; 5(11):e646. PMID: 34901755
Mastocytosis is a hematologic neoplasm characterized by expansion and focal accumulation of neoplastic mast cells (MC) in diverse organs, including the skin, bone marrow (BM), spleen, liver, and gastrointestinal tract....
10.
Mateja A, Wang Q, Chovanec J, Kim J, Wilson K, Schwartz L, et al.
J Allergy Clin Immunol . 2021 Aug; 149(3):1010-1017.e10. PMID: 34425177
Background: Acute increases of ≥20% + 2 ng/mL (20 + 2 rule) over basal serum tryptase (BST) is the recommended threshold supporting a clinical diagnosis of anaphylaxis. Prospective studies have...