Laurie K Read
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Explore the profile of Laurie K Read including associated specialties, affiliations and a list of published articles.
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69
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1461
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Recent Articles
1.
Dubey A, Tylec B, Yi S, Tedeschi F, Smith J, Read L
Nucleic Acids Res
. 2024 Dec;
53(2.
PMID: 39673519
Uridine insertion/deletion editing of mitochondrial messenger RNAs (mRNAs) in kinetoplastids entails the coordinated action of three complexes. RNA Editing Catalytic Complexes (RECCs) catalyze the enzymatic reactions, while the RNA Editing...
2.
Pandey P, Wackowski K, Dubey A, Read L
RNA
. 2024 Dec;
31(2):245-257.
PMID: 39658097
Uridine insertion/deletion (U-indel) RNA editing of mitochondrial transcripts is a posttranscriptional modification in kinetoplastid organisms, resulting in the generation of mature mRNAs from cryptic precursors. This RNA editing process involves...
3.
Bard J, Tylec B, Dubey A, Lamb N, Yergeau D, Read L
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2403188121.
PMID: 38990950
The kinetoplastid parasite, , undergoes a complex life cycle entailing slender and stumpy bloodstream forms in mammals and procyclic and metacyclic forms (MFs) in tsetse fly hosts. The numerous gene...
4.
Wackowski K, Zhu X, Shen S, Zhang M, Qu J, Read L
Nucleic Acids Res
. 2024 Jul;
52(16):9867-9885.
PMID: 38967000
Mitochondrial transcripts in Trypanosoma brucei require extensive uridine insertion/deletion RNA editing to generate translatable open reading frames. The RNA editing substrate binding complex (RESC) serves as the scaffold that coordinates...
5.
Militello K, Leigh J, Pusateri M, Read L, Vogler D
PLoS One
. 2024 Apr;
19(4):e0298521.
PMID: 38662801
In Trypanosoma brucei, gene expression is primarily regulated posttranscriptionally making RNA metabolism critical. T. brucei has an epitranscriptome containing modified RNA bases. Yet, the identity of the enzymes catalyzing modified...
6.
Smith Jr J, Tylec B, Naguleswaran A, Roditi I, Read L
mBio
. 2023 Oct;
14(5):e0185423.
PMID: 37795988
is the unicellular parasite that causes African sleeping sickness and nagana disease in livestock. The parasite has a complex life cycle consisting of several developmental forms in the human and...
7.
Ciganda M, Sotelo-Silveira J, Dubey A, Pandey P, Smith J, Shen S, et al.
RNA
. 2023 Sep;
29(12):1881-1895.
PMID: 37730435
occupies distinct niches throughout its life cycle, within both the mammalian and tsetse fly hosts. The immunological and biochemical complexity and variability of each of these environments require a reshaping...
8.
Dubey A, Tylec B, Mishra A, Sortino K, Chen R, Sun Y, et al.
Nucleic Acids Res
. 2023 May;
51(11):5791-5809.
PMID: 37140035
Mitochondrial U-indel RNA editing in kinetoplastid protozoa is directed by trans-acting gRNAs and mediated by a holoenzyme with associated factors. Here, we examine the function of the holoenzyme-associated KREH1 RNA...
9.
Ciganda M, Sotelo-Silveira J, Smith J, Shen S, Qu J, Smircich P, et al.
bioRxiv
. 2023 Feb;
PMID: 36798237
occupies distinct niches throughout its life cycle, within both the mammalian and tsetse fly hosts. The immunological and biochemical complexity and variability of each of these environments require a reshaping...
10.
Sortino K, Tylec B, Chen R, Sun Y, Read L
RNA
. 2022 Sep;
28(11):1496-1508.
PMID: 36096641
Uridine insertion/deletion RNA editing is an extensive post-transcriptional modification of mitochondrial mRNAs in kinetoplastid organisms, including This process is carried out using -acting gRNAs and complex protein machinery. The essential...