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Laurentiu M Pop

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Articles 33
Citations 450
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Recent Articles
1.
Yaman S, Ramachandramoorthy H, Iyer P, Chintapula U, Nguyen T, Sabnani M, et al.
Bioact Mater . 2024 Jan; 34:422-435. PMID: 38282968
Cell membrane-derived nanoparticles (NPs) have recently gained popularity due to their desirable features in drug delivery such as mimicking properties of native cells, impeding systemic clearance, and altering foreign body...
2.
Zhang F, Mulvaney O, Salcedo E, Manna S, Zhu J, Wang T, et al.
Cancers (Basel) . 2023 Dec; 15(23). PMID: 38067390
The early events that lead to the inflammatory and immune-modulatory effects of radiation therapy (RT) in the tumor microenvironment (TME) after its DNA damage response activating the innate DNA-sensing pathways...
3.
Mundra V, Yang Y, von Itzstein M, Fattah F, Gonugunta A, Hannan R, et al.
Transl Oncol . 2023 Jun; 34:101689. PMID: 37285748
Introduction: Preclinical studies have demonstrated the ability of radiation therapy (RT) to augment immune response and tumor control by immune checkpoint inhibitors (ICI). However, numerous clinical trials combining RT and...
4.
Hannan R, McLaughlin M, Pop L, Pedrosa I, Kapur P, Garant A, et al.
Eur Urol . 2023 Mar; 84(3):275-286. PMID: 36898872
Background: Most renal cell carcinomas (RCCs) are localized and managed by active surveillance, surgery, or minimally invasive techniques. Stereotactic ablative radiation (SAbR) may provide an innovative non-invasive alternative although prospective...
5.
Hannan R, Dohopolski M, Pop L, Mannala S, Watumull L, Mathews D, et al.
Biomedicines . 2022 Jun; 10(6). PMID: 35740441
(1) We hypothesized that adding concurrent stereotactic ablative radiotherapy (SAbR) would increase the time to progression in patients with metastatic castrate-resistant prostate cancer (mCRPCA) treated with sipuleucel-T. (2) Patients with...
6.
Bobulescu I, Pop L, Mani C, Turner K, Rivera C, Khatoon S, et al.
Metabolites . 2021 Sep; 11(9). PMID: 34564424
Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits. These deposits are thought...
7.
Hannan R, Mohamad O, De Leon A, Manna S, Pop L, Zhang Z, et al.
Clin Cancer Res . 2021 Sep; 27(24):6716-6725. PMID: 34551906
Purpose: This phase II clinical trial evaluated whether the addition of stereotactic ablative radiotherapy (SAbR), which may promote tumor antigen presentation, improves the overall response rate (ORR) to high-dose IL2...
8.
Ding L, Yu Y, Edmondson E, Weil M, Pop L, McCarthy M, et al.
Sci Rep . 2021 Jul; 11(1):14052. PMID: 34234215
High-charge, high-energy ion particle (HZE) radiations are extraterrestrial in origin and characterized by high linear energy transfer (high-LET), which causes more severe cell damage than low-LET radiations like γ-rays or...
9.
Moore C, Hsu C, Chen W, Chen B, Han C, Story M, et al.
Int J Radiat Oncol Biol Phys . 2021 Apr; 110(5):1306-1316. PMID: 33794306
Purpose: Harnessing the immune-stimulatory effects of radiation by combining it with immunotherapy is a promising new treatment strategy. However, more studies characterizing immunotherapy and radiation dose scheduling for the optimal...
10.
Margulis V, Freifeld Y, Pop L, Manna S, Kapur P, Pedrosa I, et al.
Int J Radiat Oncol Biol Phys . 2021 Feb; 110(4):1135-1142. PMID: 33549705
Purpose: To evaluate the feasibility, safety, oncologic outcomes, and immune effect of neoadjuvant stereotactic radiation (Neo-SAbR) followed by radical nephrectomy and thrombectomy (RN-IVCT). Methods And Materials: These are results from...