Laurent Malivert
Overview
Explore the profile of Laurent Malivert including associated specialties, affiliations and a list of published articles.
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10
Citations
631
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Recent Articles
1.
Shahid T, Soroka J, Kong E, Malivert L, McIlwraith M, Pape T, et al.
Nat Struct Mol Biol
. 2014 Oct;
21(11):962-968.
PMID: 25282148
Mutations in BRCA2 increase susceptibility to breast, ovarian and prostate cancers. The product of human BRCA2, BRCA2 protein, has a key role in the repair of DNA double-strand breaks and...
2.
Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans
Vera G, Rivera-Munoz P, Abramowski V, Malivert L, Lim A, Bole-Feysot C, et al.
Mol Cell Biol
. 2012 Dec;
33(4):701-11.
PMID: 23207905
Cernunnos is a DNA repair factor of the nonhomologous end-joining machinery. Its deficiency in humans causes radiosensitive severe combined immune deficiency (SCID) with microcephaly, characterized in part by a profound...
3.
Malivert L, Ropars V, Nunez M, Drevet P, Miron S, Faure G, et al.
J Biol Chem
. 2010 Jun;
285(34):26475-83.
PMID: 20558749
In mammals, the majority of DNA double-strand breaks are processed by the nonhomologous end-joining (NHEJ) pathway, composed of seven factors: Ku70, Ku80, DNA-PKcs, Artemis, Xrcc4 (X4), DNA-ligase IV (L4), and...
4.
Malivert L, Callebaut I, Rivera-Munoz P, Fischer A, Mornon J, Revy P, et al.
Mol Cell Biol
. 2008 Dec;
29(5):1116-22.
PMID: 19103754
The core nonhomologous end-joining DNA repair pathway is composed of seven factors: Ku70, Ku80, DNA-PKcs, Artemis, XRCC4 (X4), DNA ligase IV (L4), and Cernunnos/XLF (Cernunnos). Although Cernunnos and X4 are...
5.
Plo I, Nakatake M, Malivert L, de Villartay J, Giraudier S, Villeval J, et al.
Blood
. 2008 Jun;
112(4):1402-12.
PMID: 18515659
The JAK2(V617F) mutation is frequently observed in classical myeloproliferative disorders, and disease progression is associated with a biallelic acquisition of the mutation occurring by mitotic recombination. In this study, we...
6.
Rivera-Munoz P, Malivert L, Derdouch S, Azerrad C, Abramowski V, Revy P, et al.
Eur J Immunol
. 2007 Nov;
37 Suppl 1:S71-82.
PMID: 17972348
B and T lymphocytes are exposed to various genotoxic stresses during their life, which originate from programmed molecular mechanisms during their development and maturation or are secondary to cellular metabolism...
7.
Wu P, Frit P, Malivert L, Revy P, Biard D, Salles B, et al.
J Biol Chem
. 2007 Aug;
282(44):31937-43.
PMID: 17720816
Cernunnos-XLF is the most recently identified core component in the nonhomologous end-joining (NHEJ) pathway for the repair of DNA double strand breaks (DSBs) in mammals. It associates with the XRCC4/ligase...
8.
Revy P, Malivert L, de Villartay J
Curr Opin Allergy Clin Immunol
. 2006 Nov;
6(6):416-20.
PMID: 17088645
Purpose Of Review: The analysis of immune deficiency conditions in humans has recently allowed the identification of a novel factor, Cernunnos, involved in DNA repair and required during the development...
9.
Callebaut I, Malivert L, Fischer A, Mornon J, Revy P, de Villartay J
J Biol Chem
. 2006 Mar;
281(20):13857-60.
PMID: 16571728
DNA double strand breaks are considered as the most harmful DNA lesions and are repaired by either homologous recombination or nonhomologous end joining (NHEJ). A new NHEJ factor, Cernunnos, has...
10.
Buck D, Malivert L, De Chasseval R, Barraud A, Fondaneche M, Sanal O, et al.
Cell
. 2006 Jan;
124(2):287-99.
PMID: 16439204
DNA double-strand breaks (DSBs) occur at random upon genotoxic stresses and represent obligatory intermediates during physiological DNA rearrangement events such as the V(D)J recombination in the immune system. DSBs, which...