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Laurent Bultot

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Articles 27
Citations 956
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Recent Articles
1.
Pierre L, Juszczak F, Delmotte V, Decarnoncle M, Ledoux B, Bultot L, et al.
Autophagy . 2024 Dec; :1-21. PMID: 39675352
Renal proximal tubules are a primary site of injury in metabolic diseases. In obese patients and animal models, proximal tubular epithelial cells (PTECs) display dysregulated lipid metabolism, organelle dysfunctions, and...
2.
De Loof M, Renguet E, Ginion A, Bouzin C, Horman S, Beauloye C, et al.
Am J Physiol Heart Circ Physiol . 2023 Jan; 324(3):H305-H317. PMID: 36607800
Fatty acids (FAs) rapidly and efficiently reduce cardiac glucose uptake in the Randle cycle or glucose-FA cycle. This fine-tuned physiological regulation is critical to allow optimal substrate allocation during fasted...
3.
Renguet E, De Loof M, Fourny N, Ginion A, Bouzin C, Pous C, et al.
Am J Physiol Heart Circ Physiol . 2022 Apr; 322(6):H1032-H1043. PMID: 35486479
Our group previously demonstrated that an excess of nutrients, as observed in diabetes, provokes an increase in cardiac protein acetylation responsible for a reduced insulin-stimulated translocation of the glucose transporter...
4.
Peugnet V, Chwastyniak M, Mulder P, Lancel S, Bultot L, Fourny N, et al.
Antioxidants (Basel) . 2022 Apr; 11(4). PMID: 35453408
Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction, suggesting that...
5.
Dontaine J, Bouali A, Daussin F, Bultot L, Vertommen D, Martin M, et al.
Commun Biol . 2022 Apr; 5(1):349. PMID: 35414690
Protein O-GlcNAcylation is increasingly recognized as an important cellular regulatory mechanism, in multiple organs including the heart. However, the mechanisms leading to O-GlcNAcylation in mitochondria and the consequences on their...
6.
Denis M, Dupas T, Persello A, Dontaine J, Bultot L, Betus C, et al.
Int J Mol Sci . 2021 Sep; 22(17). PMID: 34502162
Sepsis in the young population, which is particularly at risk, is rarely studied. -GlcNAcylation is a post-translational modification involved in cell survival, stress response and metabolic regulation. -GlcNAc stimulation is...
7.
Bertrand L, De Loof M, Beauloye C, Horman S, Bultot L
Biochem J . 2021 Apr; 478(7):1315-1319. PMID: 33821970
Loss of the insulin-stimulated glucose uptake in muscle is a crucial event participating in the defect of whole-body metabolism in type 2 diabetes. Therefore, identification by Pavarotti et al. (Biochem....
8.
Ferte L, Marino A, Battault S, Bultot L, Van Steenbergen A, Bol A, et al.
Am J Physiol Heart Circ Physiol . 2021 Jan; 320(2):H838-H853. PMID: 33416451
Although sodium glucose cotransporter 1 (SGLT1) has been identified as one of the major SGLT isoforms expressed in the heart, its exact role remains elusive. Evidence using phlorizin, the most...
9.
Dupas T, Denis M, Dontaine J, Persello A, Bultot L, Erraud A, et al.
Acta Physiol (Oxf) . 2020 Oct; 231(3):e13566. PMID: 33022862
Aim: Metabolic sources switch from carbohydrates in utero, to fatty acids after birth and then a mix once adults. O-GlcNAcylation (O-GlcNAc) is a post-translational modification considered as a nutrient sensor....
10.
Collodet C, Foretz M, Deak M, Bultot L, Metairon S, Viollet B, et al.
FASEB J . 2019 Aug; 33(11):12374-12391. PMID: 31404503
AMPK is a central regulator of energy homeostasis. AMPK not only elicits acute metabolic responses but also promotes metabolic reprogramming and adaptations in the long-term through regulation of specific transcription...