Laurence Pibouin-Fragner
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Explore the profile of Laurence Pibouin-Fragner including associated specialties, affiliations and a list of published articles.
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16
Citations
594
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Recent Articles
1.
Furtado J, Geraldo L, Leser F, Bartkowiak B, Poulet M, Park H, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2408674121.
PMID: 39693351
The integrity of the blood-retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between the blood and surrounding neuronal cells. Breakdown of the BRB...
2.
Poulos M, Ramalingam P, Winiarski A, Gutkin M, Katsnelson L, Carter C, et al.
Stem Cell Rev Rep
. 2024 Mar;
20(4):1135-1149.
PMID: 38438768
In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine...
3.
Furtado J, Geraldo L, Leser F, Poulet M, Park H, Pibouin-Fragner L, et al.
bioRxiv
. 2023 Jan;
PMID: 36711611
Background: The blood brain barrier (BBB) preserves neuronal function in the central nervous system (CNS) by tightly controlling metabolite exchanges with the blood. In the eye, the retina is likewise...
4.
Pibouin-Fragner L, Eichmann A, Pardanaud L
Cell Mol Life Sci
. 2022 Aug;
79(9):491.
PMID: 35987946
Endothelial cells in veins differ in morphology, function and gene expression from those in arteries and lymphatics. Understanding how venous and arterial identities are induced during development is required to...
5.
Boye K, Geraldo L, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, et al.
Nat Commun
. 2022 Mar;
13(1):1169.
PMID: 35246514
Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system (CNS). Here, we show that the endothelial Unc5B receptor controls BBB integrity by maintaining Wnt/β-catenin signaling....
6.
Geraldo L, Xu Y, Jacob L, Pibouin-Fragner L, Rao R, Maissa N, et al.
J Clin Invest
. 2021 Jun;
131(16).
PMID: 34181595
SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and 2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in gliomas. In patients with...
7.
Genet G, Boye K, Mathivet T, Ola R, Zhang F, Dubrac A, et al.
Nat Commun
. 2019 May;
10(1):2350.
PMID: 31138815
Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of VEGFR2. However, how these cell behaviors are regulated individually is still unknown. Here we identify Endophilin-A2 (ENDOA2), a...
8.
Ola R, Kunzel S, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, et al.
Circulation
. 2018 Jul;
138(21):2379-2394.
PMID: 29976569
Background: Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin ( ENG) and activin-receptor-like kinase 1 ( AVCRL1 encoding...
9.
Zhang F, Prahst C, Mathivet T, Pibouin-Fragner L, Zhang J, Genet G, et al.
Nat Commun
. 2016 Nov;
7:13517.
PMID: 27882935
Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4 mice...
10.
Pardanaud L, Pibouin-Fragner L, Dubrac A, Mathivet T, English I, Brunet I, et al.
Circ Res
. 2016 Jun;
119(5):607-20.
PMID: 27354211
Rationale: Arterial endothelial cells are morphologically, functionally, and molecularly distinct from those found in veins and lymphatic vessels. How arterial fate is acquired during development and maintained in adult vessels...