Laurence Decourty
Overview
Explore the profile of Laurence Decourty including associated specialties, affiliations and a list of published articles.
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18
Citations
631
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Recent Articles
1.
Barbarin-Bocahu I, Ulryck N, Rigobert A, Ruiz Gutierrez N, Decourty L, Raji M, et al.
PLoS Biol
. 2024 Sep;
22(9):e3002821.
PMID: 39331656
The nonsense-mediated mRNA decay (NMD) pathway clears eukaryotic cells of mRNAs containing premature termination codons (PTCs) or normal stop codons located in specific contexts. It therefore plays an important role...
2.
Audebert L, Feuerbach F, Zedan M, Schurch A, Decourty L, Namane A, et al.
EMBO J
. 2024 Sep;
43(24):6496-6524.
PMID: 39322754
RNA stability, important for eukaryotic gene expression, is thought to depend on deadenylation rates, with shortened poly(A) tails triggering decapping and 5' to 3' degradation. In contrast to this view,...
3.
Decourty L, Malabat C, Frachon E, Jacquier A, Saveanu C
Nucleic Acids Res
. 2021 Aug;
49(15):8535-8555.
PMID: 34358317
Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic...
4.
Bragantini B, Charron C, Bourguet M, Paul A, Tiotiu D, Rothe B, et al.
Nat Commun
. 2021 Mar;
12(1):1859.
PMID: 33767140
Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally and requires the action of the assembly machinery including the Hsp90/R2TP complex, the Rsa1p:Hit1p heterodimer and the Bcd1 protein. We...
5.
Rossignol T, Znaidi S, Chauvel M, Wesgate R, Decourty L, Menard-Szczebara F, et al.
Antimicrob Agents Chemother
. 2021 Jan;
65(4).
PMID: 33468481
Preservatives increase the shelf life of cosmetic products by preventing growth of contaminating microbes, including bacteria and fungi. In recent years, the Scientific Committee on Consumer Safety (SCCS) has recommended...
6.
Dehecq M, Decourty L, Namane A, Proux C, Kanaan J, Le Hir H, et al.
EMBO J
. 2018 Oct;
37(21).
PMID: 30275269
Nonsense-mediated mRNA decay (NMD) is a translation-dependent RNA degradation pathway involved in many cellular pathways and crucial for telomere maintenance and embryo development. Core NMD factors Upf1, Upf2 and Upf3...
7.
Kanaan J, Raj S, Decourty L, Saveanu C, Croquette V, Le Hir H
Nat Commun
. 2018 Sep;
9(1):3752.
PMID: 30218034
Helicases are molecular engines which translocate along nucleic acids (NA) to unwind double-strands or remodel NA-protein complexes. While they have an essential role in genome structure and expression, the rules...
8.
Plateau P, Saveanu C, Lestini R, Dauplais M, Decourty L, Jacquier A, et al.
Sci Rep
. 2017 Mar;
7:44761.
PMID: 28303947
Selenomethionine, a dietary supplement with beneficial health effects, becomes toxic if taken in excess. To gain insight into the mechanisms of action of selenomethionine, we screened a collection of ≈5900...
9.
Decourty L, Doyen A, Malabat C, Frachon E, Rispal D, Seraphin B, et al.
Cell Rep
. 2014 Feb;
6(4):593-8.
PMID: 24529707
Nonsense-mediated mRNA decay (NMD) destabilizes eukaryotic transcripts with long 3' UTRs. To investigate whether other transcript features affect NMD, we generated yeast strains expressing chromosomal-derived mRNAs with 979 different promoter...
10.
Defenouillere Q, Yao Y, Mouaikel J, Namane A, Galopier A, Decourty L, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(13):5046-51.
PMID: 23479637
Ribosome stalling on eukaryotic mRNAs triggers cotranslational RNA and protein degradation through conserved mechanisms. For example, mRNAs lacking a stop codon are degraded by the exosome in association with its...