Laurence C Cheung
Overview
Explore the profile of Laurence C Cheung including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
224
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0
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Recent Articles
1.
Kotecha R, Trinder S, Hughes A, Mullin B, Rashid S, Yuan J, et al.
Blood Cancer J
. 2025 Feb;
15(1):25.
PMID: 40016188
No abstract available.
2.
Gao W, Karsa M, Xiao L, Spurling D, Karsa A, Ronca E, et al.
Int J Cancer
. 2025 Feb;
PMID: 39985426
Cancer cells are addicted to polyamines, polycations essential for cellular function. While dual targeting of cellular polyamine biosynthesis and polyamine uptake is under clinical investigation in solid cancers, preclinical and...
3.
Chiu S, Ferrari E, Oommen J, Malinge S, Cheung L, Kotecha R
Cancers (Basel)
. 2025 Feb;
17(3).
PMID: 39941894
: Infants with -rearranged B-cell acute lymphoblastic leukemia (ALL) have high rates of relapse and poor survival compared with children. Few new therapies have been identified over the past twenty...
4.
Carey-Smith S, Kotecha R, Cheung L, Malinge S
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 38999925
Copy number alterations (CNAs), resulting from the gain or loss of genetic material from as little as 50 base pairs or as big as entire chromosome(s), have been associated with...
5.
Hughes A, Kuek V, Oommen J, Kotecha R, Cheung L
Sci Rep
. 2024 May;
14(1):12396.
PMID: 38811646
The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture...
6.
Panting R, Kotecha R, Cheung L
Exp Hematol
. 2024 Mar;
133:104212.
PMID: 38552942
Extensive research over the past 50 years has resulted in significant improvements in survival for patients diagnosed with leukemia. Despite this, a subgroup of patients harboring high-risk genetic alterations still...
7.
Carey-Smith S, Simad M, Panchal K, Aya-Bonilla C, Smolders H, Lin S, et al.
Haematologica
. 2024 Mar;
109(7):2309-2315.
PMID: 38426275
No abstract available.
8.
Karsa M, Xiao L, Ronca E, Bongers A, Spurling D, Karsa A, et al.
J Mol Med (Berl)
. 2024 Feb;
102(4):507-519.
PMID: 38349407
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for...
9.
Moles E, Howard C, Huda P, Karsa M, McCalmont H, Kimpton K, et al.
Sci Transl Med
. 2023 May;
15(696):eabm1262.
PMID: 37196067
High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and...
10.
Hughes A, Kuek V, Oommen J, Chua G, van Loenhout M, Malinge S, et al.
Front Cell Dev Biol
. 2023 Feb;
11:1005494.
PMID: 36743421
Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack...