Laura ONeill
Overview
Explore the profile of Laura ONeill including associated specialties, affiliations and a list of published articles.
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22
Citations
1361
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Recent Articles
1.
Spencer Chapman M, Wilk C, Boettcher S, Mitchell E, Dawson K, Williams N, et al.
Nature
. 2024 Oct;
635(8040):926-934.
PMID: 39478227
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor. Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes...
2.
Spencer Chapman M, Cull A, Ciuculescu M, Esrick E, Mitchell E, Jung H, et al.
Nat Med
. 2023 Nov;
29(12):3175-3183.
PMID: 37973947
Gene therapy (GT) provides a potentially curative treatment option for patients with sickle cell disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials has prompted concern, with...
3.
Leongamornlert D, Gutierrez-Abril J, Lee S, Barretta E, Creasey T, Gundem G, et al.
Blood Adv
. 2023 Mar;
7(15):3862-3873.
PMID: 36867579
Genomic profiling during the diagnosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in adults is used to guide disease classification, risk stratification, and treatment decisions. Patients for whom diagnostic screening...
4.
McPeake J, Henderson P, MacTavish P, Devine H, Daniel M, Lucie P, et al.
Crit Care
. 2022 May;
26(1):152.
PMID: 35610616
Background: Caregivers and family members of Intensive Care Unit (ICU) survivors can face emotional problems following patient discharge from hospital. We aimed to evaluate the impact of a multi-centre integrated...
5.
Moore L, Cagan A, Coorens T, Neville M, Sanghvi R, Sanders M, et al.
Nature
. 2021 Aug;
597(7876):381-386.
PMID: 34433962
Over the course of an individual's lifetime, normal human cells accumulate mutations. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples...
6.
Grossmann S, Hooks Y, Wilson L, Moore L, ONeill L, Martincorena I, et al.
Cell Stem Cell
. 2021 Mar;
28(7):1262-1274.e5.
PMID: 33657416
Clonal dynamics and mutation burden in healthy human prostate epithelium are relevant to prostate cancer. We sequenced whole genomes from 409 microdissections of normal prostate epithelium across 8 donors, using...
7.
Lawson A, Abascal F, Coorens T, Hooks Y, ONeill L, Latimer C, et al.
Science
. 2020 Oct;
370(6512):75-82.
PMID: 33004514
The extent of somatic mutation and clonal selection in the human bladder remains unknown. We sequenced 2097 bladder microbiopsies from 20 individuals using targeted ( = 1914 microbiopsies), whole-exome (...
8.
DElia A, Bawor M, Dennis B, Bhatt M, Litke K, McCabe K, et al.
Pilot Feasibility Stud
. 2020 May;
6:61.
PMID: 32411381
Background: Depression impacts the lives of millions of people worldwide. Behavioral activation (BA), derived from cognitive behavioral therapy, has the potential for improving depressive symptoms in patients with depression. Studies...
9.
Lee-Six H, Olafsson S, Ellis P, Osborne R, Sanders M, Moore L, et al.
Nature
. 2019 Oct;
574(7779):532-537.
PMID: 31645730
The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer. However, our understanding of the earliest...
10.
Petljak M, Alexandrov L, Brammeld J, Price S, Wedge D, Grossmann S, et al.
Cell
. 2019 Mar;
176(6):1282-1294.e20.
PMID: 30849372
Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity...