Laura Hinze
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Explore the profile of Laura Hinze including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
309
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0
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Recent Articles
1.
Loxha L, Ibrahim N, Stasche A, Cinar B, Dolgner T, Niessen J, et al.
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686063
Amino acid availability is crucial for cancer cells' survivability. Leukemia and colorectal cancer cells have been shown to resist asparagine depletion by utilizing GSK3-dependent proteasomal degradation, termed the Wnt-dependent stabilization...
2.
Junk S, Schaeffeler E, Zimmermann M, Moricke A, Beier R, Schutte P, et al.
J Exp Clin Cancer Res
. 2023 Jan;
42(1):21.
PMID: 36639636
Background: Characterization of clinical phenotypes in context with tumor and host genomic information can aid in the development of more effective and less toxic risk-adapted and targeted treatment strategies. To...
3.
Wieland I, Diekmann F, Carlens J, Hinze L, Lambeck K, Jack T, et al.
Front Pediatr
. 2022 Dec;
10:1012738.
PMID: 36452355
Background And Objectives: Emerging evidence suggests that increased degradation of von Willebrand factor and decrease in high molecular weight multimers occurs in patients with pulmonary hypertension (PH). However, the link...
4.
Hinze L, Schreek S, Zeug A, Ibrahim N, Fehlhaber B, Loxha L, et al.
Mol Cell
. 2022 Jun;
82(15):2858-2870.e8.
PMID: 35732190
The tolerance of amino acid starvation is fundamental to robust cellular fitness. Asparagine depletion is lethal to some cancer cells, a vulnerability that can be exploited clinically. We report that...
5.
Ibrahim N, Eraky A, Eggers J, Steiert T, Sebens S, Junemann K, et al.
Cancers (Basel)
. 2022 Feb;
14(4).
PMID: 35205727
The standard diagnostic and follow-up examination for bladder cancer is diagnostic cystoscopy, an invasive test that requires compliance for a long period. Urine cytology and recent biomarkers come short of...
6.
Bartram T, Schutte P, Moricke A, Houlston R, Ellinghaus E, Zimmermann M, et al.
J Clin Med
. 2021 Nov;
10(21).
PMID: 34768335
Background: Acute pancreatitis (AP) is a serious, mechanistically not entirely resolved side effect of L-asparaginase-containing treatment for acute lymphoblastic leukemia (ALL). To find new candidate variations for AP, we conducted...
7.
Masath F, Hinze L, Nkuba M, Hecker T
J Interpers Violence
. 2021 May;
37(17-18):NP15455-NP15478.
PMID: 34011191
The need for intervention strategies aiming to reduce teachers' use of violent discipline methods has been expressed repeatedly, especially for countries where this practice is socially and legally accepted. Nevertheless,...
8.
Stanulla M, Schaeffeler E, Moricke A, Buchmann S, Zimmermann M, Igel S, et al.
Leukemia
. 2021 Mar;
35(9):2650-2657.
PMID: 33714975
Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal obstruction syndrome (SOS). Nevertheless, current treatment continues to use short-term applications...
9.
Hinze L, Labrosse R, Degar J, Han T, Schatoff E, Schreek S, et al.
Cancer Discov
. 2020 Jul;
10(11):1690-1705.
PMID: 32703769
Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently...
10.
Pouliot G, Degar J, Hinze L, Kochupurakkal B, Vo C, Burns M, et al.
PLoS One
. 2019 Nov;
14(11):e0221288.
PMID: 31721781
BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and suppresses transformation of immature T-cells in mice. However, the contribution of Fanconi-BRCA pathway deficiency to human...