Laura Comas
Overview
Explore the profile of Laura Comas including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
139
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0
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Recent Articles
1.
Senan-Salinas A, Comas L, Esteban P, Garzon-Tituana M, Cheng Z, Santiago L, et al.
ACS Pharmacol Transl Sci
. 2024 May;
7(5):1474-1484.
PMID: 38751645
Granzymes (Gzms), a family of serine proteases, expressed by immune and nonimmune cells, present perforin-dependent and independent intracellular and extracellular functions. When released in the extracellular space, GzmA, with trypsin-like...
2.
Labat-de-Hoz L, Comas L, Rubio-Ramos A, Casares-Arias J, Fernandez-Martin L, Pantoja-Uceda D, et al.
Cell Mol Life Sci
. 2022 Oct;
79(11):571.
PMID: 36306014
In INF2-a formin linked to inherited renal and neurological disease in humans-the DID is preceded by a short N-terminal extension of unknown structure and function. INF2 activation is achieved by...
3.
Lanuza P, Alonso M, Hidalgo S, Uranga-Murillo I, Garcia-Mulero S, Arnau R, et al.
Front Immunol
. 2022 Jun;
13:890836.
PMID: 35747143
Background: Colorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour progression and response to treatment. While chemoresistant and poorly immunogenic CRC...
4.
Garzon-Tituana M, Sierra-Monzon J, Comas L, Santiago L, Khaliulina-Ushakova T, Uranga-Murillo I, et al.
Theranostics
. 2021 Mar;
11(8):3781-3795.
PMID: 33664861
Peritonitis is one of the most common causes of sepsis, a serious syndrome characterized by a dysregulated systemic inflammatory response. Recent evidence suggests that Granzyme A (GzmA), a serine protease...
5.
Esteban P, Redrado S, Comas L, Domingo M, Millan-Lou M, Seral C, et al.
Toxins (Basel)
. 2021 Jan;
13(2).
PMID: 33498622
Multidrug-resistant bacteria such as methicillin-resistant (MRSA) is one of the major causes of hospital-acquired and community infections and pose a challenge to the human health care system. Therefore, it is...
6.
Santiago L, Castro M, Sanz-Pamplona R, Garzon M, Ramirez-Labrada A, Tapia E, et al.
Cell Rep
. 2020 Jul;
32(1):107847.
PMID: 32640217
If not properly regulated, the inflammatory immune response can promote carcinogenesis, as evident in colorectal cancer (CRC). Aiming to gain mechanistic insight into the link between inflammation and CRC, we...
7.
Comas L, Polo E, Domingo M, Hernandez Y, Arias M, Esteban P, et al.
Materials (Basel)
. 2019 Apr;
12(7).
PMID: 30987007
Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in...
8.
Arias M, Santiago L, Vidal-Garcia M, Redrado S, Lanuza P, Comas L, et al.
Front Immunol
. 2018 Nov;
9:2549.
PMID: 30459771
Pulmonary aspergillosis is a severe infectious disease caused by some members of the genus, that affects immunocompetent as well as immunocompromised patients. Among the different disease forms, Invasive Aspergillosis is...
9.
Nunez D, Comas L, Lanuza P, Sanchez-Martinez D, Perez-Hernandez M, Catalan E, et al.
Front Immunol
. 2018 Jan;
8:1817.
PMID: 29312326
The interaction between intercellular adhesion molecules (ICAM) and the integrin leukocyte function-associated antigen-1 (LFA-1) is crucial for the regulation of several physiological and pathophysiological processes like cell-mediated elimination of tumor...
10.
Santiago L, Menaa C, Arias M, Martin P, Jaime-Sanchez P, Metkar S, et al.
Arthritis Rheumatol
. 2016 Sep;
69(2):320-334.
PMID: 27598995
Objective: Granzyme A (GzmA) levels are elevated in the plasma and synovium of patients with rheumatoid arthritis (RA), suggesting involvement of this protease in the pathogenesis of the disease. GzmA...