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Laura C Demmers

Explore the profile of Laura C Demmers including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Mukherjee S, Sanchez-Bernabeu A, Demmers L, Wu W, Heck A
Front Immunol . 2021 Dec; 12:796584. PMID: 34925382
Mass-spectrometry based immunopeptidomics has provided unprecedented insights into antigen presentation, not only charting an enormous ligandome of self-antigens, but also cancer neoantigens and peptide antigens harbouring post-translational modifications. Here we...
2.
Hoek M, Demmers L, Wu W, Heck A
J Proteome Res . 2021 Aug; 20(9):4518-4528. PMID: 34415762
Presentation of antigens by human leukocyte antigen (HLA) complexes at the cell surface is a key process in the immune response. The α-chain, containing the peptide-binding groove, is one of...
3.
Demmers L, Wu W, Heck A
Mol Cell Proteomics . 2021 May; 20:100089. PMID: 33933681
Human leukocyte antigen (HLA) molecules play critical roles in our adaptive immune system by signaling a cell's health status to the immune system, through presentation of small peptides. Understanding HLA...
4.
Demmers L, Kretzschmar K, Van Hoeck A, Bar-Epraim Y, van den Toorn H, Koomen M, et al.
Nat Commun . 2020 Oct; 11(1):5338. PMID: 33087703
Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising leads to invoke...
5.
Demmers L, Heck A, Wu W
J Proteome Res . 2019 Feb; 18(4):1634-1643. PMID: 30784271
HLA class Ι molecules can communicate a range of cellular alterations (mutations, changes in protein copy number, aberrant post-translational modifications, or pathogen proteins) to CD8+ T lymphocytes in the form...