Laura C D Pomatto
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Explore the profile of Laura C D Pomatto including associated specialties, affiliations and a list of published articles.
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23
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923
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Recent Articles
11.
Davies J, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, et al.
Geroscience
. 2017 Dec;
39(5-6):499-550.
PMID: 29270905
A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How...
12.
Walker C, Pomatto L, Tripathi D, Davies K
Physiol Rev
. 2017 Nov;
98(1):89-115.
PMID: 29167332
Peroxisomes are highly dynamic intracellular organelles involved in a variety of metabolic functions essential for the metabolism of long-chain fatty acids, d-amino acids, and many polyamines. A byproduct of peroxisomal...
13.
Pomatto L, Wong S, Tower J, Davies K
Arch Biochem Biophys
. 2017 Nov;
636:57-70.
PMID: 29100984
Sexual dimorphism includes the physical and reproductive differences between the sexes, including differences that are conserved across species, ranging from the common fruit fly, Drosophila melanogaster, to humans. Sex-dependent variations...
14.
Pomatto L, Davies K
J Physiol
. 2017 Oct;
595(24):7275-7309.
PMID: 29028112
Adaptive homeostasis is "the transient expansion or contraction of the homeostatic range for any given physiological parameter in response to exposure to sub-toxic, non-damaging, signalling molecules or events, or the...
15.
Pomatto L, Tower J, Davies K
J Gerontol A Biol Sci Med Sci
. 2017 May;
73(2):141-149.
PMID: 28525535
External and internal stimuli cause modifications to gene and biochemical pathways. In turn, demonstrating that biological systems continuously make short-term adaptations both to set-points, and to the range of "normal"...
16.
Pomatto L, Wong S, Carney C, Shen B, Tower J, Davies K
Aging (Albany NY)
. 2017 Apr;
9(4):1153-1185.
PMID: 28373600
Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C...
17.
Pomatto L, Carney C, Shen B, Wong S, Halaszynski K, Salomon M, et al.
Curr Biol
. 2016 Dec;
27(1):1-15.
PMID: 27916526
Multiple human diseases involving chronic oxidative stress show a significant sex bias, including neurodegenerative diseases, cancer, immune dysfunction, diabetes, and cardiovascular disease. However, a possible molecular mechanism for the sex...
18.
Raynes R, Juarez C, Pomatto L, Sieburth D, Davies K
J Gerontol A Biol Sci Med Sci
. 2016 Jun;
72(2):143-151.
PMID: 27341854
Aging is marked by a collapse of protein homeostasis and deterioration of adaptive stress responses that often lead to disease. During aging, the induction of stress responses decline along with...
19.
Raynes R, Pomatto L, Davies K
Mol Aspects Med
. 2016 May;
50:41-55.
PMID: 27155164
The proteasome is a ubiquitous and highly plastic multi-subunit protease with multi-catalytic activity that is conserved in all eukaryotes. The most widely known function of the proteasome is protein degradation...
20.
Johnston-Carey H, Pomatto L, Davies K
Crit Rev Biochem Mol Biol
. 2016 Apr;
51(4):268-81.
PMID: 27098648
The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the major histocompatibility complex, which is critical for immunity. However, recent research has...