Laura C D Pomatto
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Explore the profile of Laura C D Pomatto including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Rowan S, Jiang S, Francisco S, Pomatto L, Ma Z, Jiao X, et al.
Invest Ophthalmol Vis Sci
. 2021 Dec;
62(15):10.
PMID: 34882206
Purpose: Age-related cataracts affect the majority of older adults and are a leading cause of blindness worldwide. Treatments that delay cataract onset or severity have the potential to delay cataract...
2.
Wiedmer P, Jung T, Castro J, Pomatto L, Sun P, Davies K, et al.
Ageing Res Rev
. 2020 Nov;
65:101200.
PMID: 33130247
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the...
3.
Pomatto L, Sisliyan C, Wong S, Cline M, Tower J, Davies K
Free Radic Biol Med
. 2020 Aug;
160:67-77.
PMID: 32758664
Our studies center on the physiological phenomenon of adaptive homeostasis in which very low, signaling levels of an oxidant can induce transient expansion of the baseline homeostatic range of protective...
4.
Tower J, Pomatto L, Davies K
Redox Biol
. 2020 Mar;
31:101488.
PMID: 32201219
Sex differences in diseases involving oxidative and proteolytic stress are common, including greater ischemic heart disease, Parkinson disease and stroke in men, and greater Alzheimer disease in women. Sex differences...
5.
Pomatto L, Dill T, Carboneau B, Levan S, Kato J, Mercken E, et al.
Free Radic Biol Med
. 2020 Jan;
152:650-658.
PMID: 31953150
Caloric restriction (CR) is the leading non-pharmaceutical dietary intervention to improve health- and lifespan in most model organisms. A wide array of cellular pathways is induced in response to CR...
6.
Pomatto L, Sun P, Yu K, Gullapalli S, Bwiza C, Sisliyan C, et al.
Redox Biol
. 2019 Apr;
24:101194.
PMID: 31022673
The Nrf2 signal transduction pathway plays a major role in adaptive responses to oxidative stress and in maintaining adaptive homeostasis, yet Nrf2 signaling undergoes a significant age-dependent decline that is...
7.
Pomatto L, Davies K
Free Radic Biol Med
. 2018 Jul;
124:420-430.
PMID: 29960100
The Free Radical Theory of Ageing, was first proposed by Denham Harman in the mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At its core, the...
8.
Pomatto L, Sun P, Davies K
Mech Ageing Dev
. 2018 May;
177:80-87.
PMID: 29778759
Many consequences of ageing can be broadly attributed to the inability to maintain homeostasis. Multiple markers of ageing have been identified, including loss of protein homeostasis, increased inflammation, and declining...
9.
Pomatto L, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan T, et al.
Free Radic Biol Med
. 2018 May;
121:86-97.
PMID: 29709705
Environmental toxicants are catalysts for protein damage, aggregation, and the aging process. Fortunately, evolution selected adaptive homeostasis as a system to mitigate such damage by expanding the normal capacity to...
10.
Pomatto L, Wong S, Tower J, Davies K
Data Brief
. 2018 Mar;
17:653-661.
PMID: 29552615
Adaptive homeostasis enables rapid cellular signaling, leading to transcriptional and translational modifications (Davies, 2016) [1]. The Proteasome is one of the main cellular proteolytic enzymes that plays an essential role...